Virusinjektion stoppar tillväxt av bukspottkörteltumörer i klinisk prövning

Ett genetiskt modifierat virus har stoppat tillväxten av bukspottkörteltumörer hos tre patienter i en tidig amerikansk klinisk prövning. Resultaten kommer från en säkerhetsstudie ledd av forskare vid University of Minnesota.

Den första patienten fick behandlingen för ett år sedan efter diagnosen av en 7 centimeter stor tumör begränsad till bukspottkörteln. De andra två patienterna behandlades senare, och alla tre lever fortfarande med stabil sjukdom, enligt Masato Yamamoto, som ledde utvecklingen av terapin. Endast en tiondel av den planerade dosen användes i denna inledande fas, men tumörerna har varken spridit sig eller vuxit sedan injektionen.

Relaterade artiklar

A volunteer receiving a needle-free vaccine in a lab with AI-designed virus models in the background.
Bild genererad av AI

AI-designed “pan-sarbecovirus” vaccine candidate reports early safety and immune-response signals in first human trial

Rapporterad av AI Bild genererad av AI Faktagranskad

A needle-free, DNA-based vaccine candidate designed using machine-learning methods has completed a first-in-human Phase 1 study in the UK, with researchers reporting it was well tolerated and induced immune responses against multiple viruses in the sarbecovirus group, which includes SARS-CoV, SARS-CoV-2 and related bat coronaviruses.

Researchers have used genetically modified phages to harness pre-existing vaccine immunity and destroy cancer cells in mice. The approach eradicated tumors in 44 percent of treated animals with no recurrence after a year.

Rapporterad av AI

Researchers at Oregon State University have developed an experimental treatment that uses sugar-coated nanoparticles to deliver genetic material across the blood-brain barrier in a mouse model of glioblastoma. The approach restored a tumor-suppressing protein and increased median survival by 50 percent while shrinking tumors without measurable organ toxicity.

Researchers at McGill University report a drug-based method to temporarily enhance natural killer (NK) cells—an immune cell type—by inhibiting two proteins, improving the cells’ ability to attack several aggressive cancers in preclinical experiments.

Rapporterad av AI

Researchers at USC Stem Cell have developed a method to produce large numbers of immune cell precursors that can be engineered to target cancer. The approach, published in the journal Cell, uses granulocyte-monocyte progenitors that self-renew in the laboratory.

An experimental therapy called VERVE-102 lowered LDL cholesterol by up to 62 percent after a single dose in an early safety study. The results come from a Phase I trial involving 35 patients with high cholesterol or early cardiovascular disease. Data were published this week in the New England Journal of Medicine.

Denna webbplats använder cookies

Vi använder cookies för analys för att förbättra vår webbplats. Läs vår integritetspolicy för mer information.
Avböj