米国の初期臨床試験において、遺伝子操作されたウイルスが膵臓腫瘍の増殖を停止させたことが報告された。この結果は、ミネソタ大学の研究チームが主導した安全性試験によるものである。
最初の患者は1年前に膵臓に7センチメートルの腫瘍があると診断された後、この治療を受けた。開発を主導した山本雅人氏によると、他の2名の患者もその後に治療を受け、3名とも病状は安定しており生存している。今回の初期段階では計画された投与量のわずか10分の1が使用されたにもかかわらず、投与以降、腫瘍の転移や増大は見られていない。
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A needle-free, DNA-based vaccine candidate designed using machine-learning methods has completed a first-in-human Phase 1 study in the UK, with researchers reporting it was well tolerated and induced immune responses against multiple viruses in the sarbecovirus group, which includes SARS-CoV, SARS-CoV-2 and related bat coronaviruses.
Researchers have used genetically modified phages to harness pre-existing vaccine immunity and destroy cancer cells in mice. The approach eradicated tumors in 44 percent of treated animals with no recurrence after a year.
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Researchers at Oregon State University have developed an experimental treatment that uses sugar-coated nanoparticles to deliver genetic material across the blood-brain barrier in a mouse model of glioblastoma. The approach restored a tumor-suppressing protein and increased median survival by 50 percent while shrinking tumors without measurable organ toxicity.
Researchers at McGill University report a drug-based method to temporarily enhance natural killer (NK) cells—an immune cell type—by inhibiting two proteins, improving the cells’ ability to attack several aggressive cancers in preclinical experiments.
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Researchers at USC Stem Cell have developed a method to produce large numbers of immune cell precursors that can be engineered to target cancer. The approach, published in the journal Cell, uses granulocyte-monocyte progenitors that self-renew in the laboratory.
An experimental therapy called VERVE-102 lowered LDL cholesterol by up to 62 percent after a single dose in an early safety study. The results come from a Phase I trial involving 35 patients with high cholesterol or early cardiovascular disease. Data were published this week in the New England Journal of Medicine.