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Fluorescence micrograph illustrating uneven PARP inhibitor accumulation in lysosomes of ovarian tumor cells, creating patchy drug exposure.
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Study links uneven PARP inhibitor exposure in ovarian tumors to lysosomal drug “reservoirs”

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Researchers say they have identified a cellular mechanism that may help explain why PARP inhibitors can affect tumor cells unevenly: in lab-grown slices of human ovarian tumors, some of these drugs accumulated inside lysosomes, forming slow-release stores that created patchy drug distribution across tissue and even between neighboring cells. The findings were reported in a 2026 paper in Nature Communications.

Supreme Court Associate Justice Maria Filomena Singh discussed her cancer battle and advocacy for gender equality in the judiciary during a Rappler interview. The episode aired on March 27 as part of Rappler Talk. As co-chairperson of the gender responsiveness committee, she pushes for reforms to better serve women in the legal system.

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A new poll reveals that nearly half of U.S. adults do not know processed meat is linked to higher colorectal cancer risk. Conducted by the Physicians Committee for Responsible Medicine and Morning Consult, the survey of 2,202 adults from February 9 to 11, 2026, found strong support for warning labels after respondents learned of the connection. Experts highlight the need for better education amid rising cases in younger adults.

Die kenianische Regierung hat das Onkologie-Behandlungspaket der Social Health Authority von Ksh 550.000 auf Ksh 800.000 pro Patient angehoben. Raymond Omollo, Principal Secretary im Innenministerium, kündigte die Erhöhung am 16. März 2026 an, inmitten öffentlicher Empörung über Behandlungskosten. Das Paket umfasst Diagnose, Chemotherapie, Strahlentherapie, Brachytherapie, chirurgische Eingriffe, palliative Pflege, Verbrauchsmaterialien sowie spezialisierte Bildgebungen wie PET/CT-Scans und MRTs in beauftragten Einrichtungen.

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Researchers tested a redesigned CD40 agonist antibody, 2141-V11, by injecting it directly into tumors of 12 patients with metastatic cancers. Six patients saw tumor shrinkage, with two achieving complete remission, including effects on untreated tumors elsewhere in the body. The trial reported only mild side effects, unlike prior CD40 therapies.

Researchers at Uppsala University are launching a new treatment study to help young adults who have had cancer address issues related to sexuality and fertility. Around 40 participants aged 18-39 are involved in a 12-week internet-based program. The study is expected to include a total of about 250 people.

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Researchers at Oregon Health & Science University have created a molecule called SU212 that blocks a key enzyme in triple-negative breast cancer cells. In mouse models, the compound reduced tumor growth and metastasis. The findings offer potential new treatment options for this hard-to-treat form of the disease.

 

 

 

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