암
Decades after a small breast cancer vaccine trial, researchers link lasting immune memory to CD27
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More than 20 years after a small Duke-led clinical trial tested an experimental breast cancer vaccine, Duke Health says all participating women are still alive—an outcome researchers describe as unusual for metastatic disease. Follow-up analyses found long-lived immune cells marked by CD27, and mouse experiments suggest that stimulating CD27 can boost vaccine-driven tumor control.
A randomized trial shows that administering cancer immunotherapy before 3pm can nearly double survival time for patients with non-small cell lung cancer. Researchers found significant benefits from aligning treatment with circadian rhythms during the initial cycles. This marks the strongest evidence yet for chronotherapy in oncology.
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Researchers in Brazil have uncovered how pancreatic cancer uses a protein called periostin to invade nerves and spread early. This discovery explains the disease's aggressiveness and suggests new treatment targets. The findings, published in Molecular and Cellular Endocrinology, highlight the tumor's ability to remodel surrounding tissue.
A new study reveals that chemotherapy's damage to the gut lining unexpectedly rewires the microbiota, producing a compound that strengthens immune defenses against cancer spread. This process reduces immunosuppressive cells and enhances resistance to metastasis, particularly in the liver. Patient data links higher levels of this compound to improved survival in colorectal cancer cases.
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New research indicates that regular use of ibuprofen, a common painkiller, may reduce the risk of endometrial cancer by up to 25% in certain women. This finding comes from a large-scale study analyzing over 42,000 participants, highlighting the drug's anti-inflammatory properties. However, experts caution against using it for prevention due to potential side effects.
Scientists at Northwestern Medicine have developed an antibody that counters pancreatic cancer's sugar-based disguise, enabling the immune system to attack tumors more effectively. In mouse studies, the therapy slowed tumor growth by restoring immune activity. The team is preparing the antibody for human trials.
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일본 후생노동성이 2016년 약 99만 건 진단 데이터를 바탕으로 전국 최초 암 환자 5년 생존율을 발표했다. 전립선암이 92.1%로 최고치를 기록한 반면, 췌장암은 11.8%로 최저였다. 국가 암 등록 데이터에서 추출된 이 수치는 암 유형 간 차이를 강조한다.
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