Study finds no widespread brain inflammation in long COVID

Researchers in Finland have found no evidence of widespread brain inflammation among people with long COVID. The findings instead link more severe symptoms to increased activity in brain regions involved in emotion and memory.

A team at the University of Turku examined 14 people with long COVID using PET and MRI scans. They compared results with scans from 11 healthy volunteers and 13 patients with multiple sclerosis. No meaningful differences in brain inflammation markers appeared between the long COVID group and healthy controls. The long COVID patients also showed far less white matter inflammation than the multiple sclerosis group.

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Illustration of mutated blood cells entering the brain through the blood-brain barrier, linked to Alzheimer's pathology.
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Study finds blood-cancer-linked mutations in brain immune cells tied to Alzheimer’s pathology

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Researchers at Boston Children’s Hospital report that mutations commonly associated with clonal blood-cell expansion and some blood cancers were enriched in microglia-like immune cells in Alzheimer’s brains and were also detectable in matched blood samples. The Cell study proposes that age- or injury-related weakening of the blood-brain barrier could allow mutated blood immune cells to enter the brain, potentially amplifying inflammation and contributing to neurodegeneration.

A common antidepressant has shown strong results against persistent fatigue caused by long COVID in a new clinical trial. The study found that fluvoxamine improved symptoms and quality of life for participants in Brazil.

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Scientists have identified a key transition in brain immune cells that may determine whether Alzheimer's pathology leads to dementia. The research, based on human brain tissue, highlights distinct microglial responses associated with resilience or decline.

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