Neuroscience
UCSF researchers test LSD-based MM120 for generalized anxiety disorder
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UCSF neuroscientist Jennifer Mitchell and collaborators are evaluating MM120, a pharmaceutical form of LSD, as a potential treatment for generalized anxiety disorder. A randomized clinical trial published in JAMA found that a single dose reduced anxiety symptoms versus placebo, with benefits persisting up to 12 weeks in the optimal dose group, according to the study and the drug’s sponsor.
Mother's voice recordings boost brain development in premature babies
A new study shows that playing recordings of a mother's voice to premature babies in intensive care can strengthen brain connections related to language processing. Researchers found that this simple intervention led to more mature neural pathways in affected infants. The findings suggest potential improvements in long-term language outcomes for preterm children.
Neurons use fat—not just sugar—for energy, study ties pathway to rare brain disorder
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Researchers in Australia and Finland report that neurons can fuel themselves with fat as well as sugar, challenging long‑held assumptions about brain energy. The discovery, published in Nature Metabolism, links a lipid‑processing enzyme to a rare hereditary spastic paraplegia and suggests that targeted fatty acid supplements may restore cellular energy in laboratory models.
Online brain training tied to decade‑equivalent boost in cholinergic function, McGill trial finds
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A double‑blind McGill University–led clinical trial reports that 10 weeks of BrainHQ exercises increased a PET marker of cholinergic function in healthy older adults by an amount the authors say roughly offsets about a decade of age‑related decline. The peer‑reviewed study used a specialized tracer to confirm the biochemical change.
Sleep deprivation triggers brain cleaning during wakefulness
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Cognitive ability tied to understanding speech in noisy settings, study finds
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Among people with clinically normal hearing, intellectual ability strongly predicted how well they understood speech amid competing voices, according to a peer-reviewed study from University of Washington researchers.
Scientists receive $14.2 million NIH award to map the body’s ‘hidden sixth sense’
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A team led by Nobel laureate Ardem Patapoutian at Scripps Research, working with collaborators at the Allen Institute, has secured a five-year, $14.2 million NIH Director’s Transformative Research Award to build what they describe as the first atlas of interoception—the internal sensory system that helps keep breathing, blood pressure and digestion in balance. ([eurekalert.org](https://www.eurekalert.org/news-releases/1101449?utm_source=openai))
Researchers directly visualize alpha‑synuclein oligomers in human Parkinson’s brain tissue
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Scientists in the U.K. and Canada report the first direct visualization and measurement of alpha‑synuclein oligomers—the small protein clusters long suspected of triggering Parkinson’s—in human brain tissue. Using an ultra‑sensitive imaging method, the team found these clusters were larger and more numerous in Parkinson’s than in age‑matched controls, a result published in Nature Biomedical Engineering that may help guide earlier diagnosis and targeted therapies.
Scientists uncover early brain damage before MS symptoms
Researchers at UC San Francisco have found that multiple sclerosis damages the brain years before symptoms appear, by analyzing blood proteins. The study identifies key markers like IL-3 and MOG, potentially enabling earlier diagnosis and prevention. This discovery, published in Nature Medicine, could transform how MS is managed.
Study links gum disease to greater white matter changes in the brain
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Research published October 22, 2025, in Neurology® Open Access reports that older adults with gum disease had more white matter hyperintensities—a marker of tissue damage—than peers without gum disease, even after accounting for other risks.
Toxic alliance of proteins may trigger Alzheimer's disease
Researchers at Rockefeller University have identified a harmful interaction between amyloid beta and fibrinogen that forms stubborn clots, damaging brain blood vessels and sparking inflammation even at low concentrations. This complex disrupts the blood-brain barrier and leads to early signs of neurodegeneration. The findings suggest a new target for early intervention in Alzheimer's disease.