Neuroscience
Study links lysosomal ion channel TMEM175 to protection against over-acidification, with implications for Parkinson’s research
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Researchers at LMU Munich, Bonn-Rhein-Sieg University of Applied Sciences, TU Darmstadt and Nanion Technologies report that the lysosomal ion channel TMEM175 helps prevent excessive acidification inside lysosomes, a malfunction that the team says could contribute to toxic buildup associated with Parkinson’s disease. The findings were reported in the Proceedings of the National Academy of Sciences.
Researchers have found that vivid, immersive dreams can make sleep feel deeper and more restorative, even during periods of high brain activity. A study analyzing brain recordings from 44 healthy adults showed that participants reported their deepest sleep after intense dream experiences. The findings challenge traditional views of deep sleep as minimal brain activity.
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Researchers at Emory University have discovered that excessive brain and muscle activity during minor balance disruptions contributes to poorer balance recovery in older adults, including those with Parkinson's disease. The study, published in eNeuro, reveals that trying harder to balance may actually increase fall risk. Opposing muscles stiffening simultaneously further impairs stability.
Researchers at Scripps Research have developed a blood test that detects Alzheimer's disease by analyzing structural changes in blood proteins. The method identifies differences in three specific proteins, allowing accurate distinction between healthy individuals, those with mild cognitive impairment, and Alzheimer's patients. Published in Nature Aging on February 27, 2026, the findings could enable earlier diagnosis and treatment.
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SIGGY, an alternative rock project led by neuroscientist Dr. Galen Buckwalter, has announced the release of its album Wirehead on March 15, 2026. The album draws inspiration from brain-computer interface research that translates neural activity into digital signals. Buckwalter's work with implanted microelectrode arrays at Caltech influenced the project's themes of consciousness and human-machine interaction.
A new genomic analysis suggests that Alzheimer's disease may begin with inflammation in organs like the skin, lungs, or gut, potentially decades before brain symptoms appear. Researchers analyzed genetic data from hundreds of thousands of people and found risk genes more active outside the brain. This perspective could reshape prevention and treatment strategies.
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Researchers at UCLA Health and UC San Francisco have identified a natural defense mechanism in brain cells that helps remove toxic tau protein, potentially explaining why some neurons resist Alzheimer's damage better than others. The study, published in Cell, used CRISPR screening on lab-grown human neurons to uncover this system. Findings suggest new therapeutic avenues for neurodegenerative diseases.
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