Slow breathing calms anxiety without mindfulness in mice study

A new study shows that slowing breathing rates can reduce anxiety-like behaviors even without any conscious effort or belief in its effects. Researchers used mice to demonstrate that the benefits come from physiological changes rather than placebo. The findings were presented at a summit in Los Angeles earlier this month.

Jack Feldman, a neuroscientist at UCLA, presented the research at the Embodied Minds Summit in Los Angeles on 3 May. His team trained mice to breathe more slowly using optogenetics, targeting neurons in the pre-Bötzinger Complex, a brainstem region that controls breathing rhythm. After four weeks, the mice maintained slower breathing and showed less fear in stressful tests compared with untrained mice.

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Scientific illustration of mouse abdominal muscle contraction transmitting pressure via spinal veins to induce subtle brain motion and cerebrospinal fluid circulation for waste removal.
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Study links abdominal muscle contractions to subtle brain motion that may help circulate cerebrospinal fluid

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Penn State researchers report that tightening the abdominal muscles can transmit pressure through a vein network along the spine, causing the brain to shift slightly inside the skull in mice. The team says computer simulations suggest this motion could help drive cerebrospinal fluid flow that is thought to support waste removal, offering one possible mechanical explanation for why everyday movement and exercise are associated with brain health.

Researchers have identified a specific group of neurons in the amygdala that plays a central role in anxiety and social withdrawal. By restoring normal activity in this circuit, they reversed anxiety-related behaviors in mice. The findings point to a potential new target for treating emotional disorders.

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Researchers have shown that stimulating specific brain activity in awake mice produces some of the restorative effects of deep sleep, including improved memory. The team now plans to explore whether a similar approach could work in people.

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