Slow breathing calms anxiety without mindfulness in mice study

A new study shows that slowing breathing rates can reduce anxiety-like behaviors even without any conscious effort or belief in its effects. Researchers used mice to demonstrate that the benefits come from physiological changes rather than placebo. The findings were presented at a summit in Los Angeles earlier this month.

Jack Feldman, a neuroscientist at UCLA, presented the research at the Embodied Minds Summit in Los Angeles on 3 May. His team trained mice to breathe more slowly using optogenetics, targeting neurons in the pre-Bötzinger Complex, a brainstem region that controls breathing rhythm. After four weeks, the mice maintained slower breathing and showed less fear in stressful tests compared with untrained mice.

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Illustration of rat brainstem neurons in the lateral parafacial region driving hypertension, with inhibition restoring normal blood pressure.
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Study links brainstem “lateral parafacial” neurons to a form of hypertension in rats

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Researchers working with the University of Auckland and Brazil’s University of São Paulo report that neurons in the medulla’s lateral parafacial (pFL) region—best known for helping drive forceful exhalations—also amplify sympathetic nerve activity and can raise blood pressure in an animal model of neurogenic hypertension. Inhibiting these neurons lowered blood pressure toward normal in hypertensive rats, findings published in Circulation Research.

A randomized clinical trial found that 24 minutes of specially designed music paired with auditory beat stimulation significantly lowers anxiety symptoms. Researchers at Toronto Metropolitan University tested various listening durations on 144 adults with moderate anxiety. The 24-minute session provided the strongest benefits.

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New research from New York University indicates that anxiety about growing older, particularly concerns over health decline, correlates with accelerated cellular aging in women. The study, involving 726 participants, used epigenetic clocks to measure biological aging rates. Fears related to appearance or fertility showed no similar connection.

A new study in Gastroenterology connects early life stress to long-term gut issues through disruptions in gut-brain communication. Mouse experiments and large human cohorts show links to pain, constipation, and irritable bowel syndrome. Researchers suggest targeted treatments based on specific biological pathways.

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Researchers at Monash University have found that adults with ADHD experience more frequent episodes of sleep-like brain activity during wakefulness, which correlates with attention lapses. The study, published in the Journal of Neuroscience, links these brief shifts to errors, slower reactions, and increased sleepiness during tasks. Lead author Elaine Pinggal suggests this mechanism underlies attention difficulties in ADHD.

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