Mental Health

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UCSF researcher Jennifer Mitchell in a lab examining MM120, an LSD-based drug for treating generalized anxiety disorder.

UCSF researchers test LSD-based MM120 for generalized anxiety disorder

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UCSF neuroscientist Jennifer Mitchell and collaborators are evaluating MM120, a pharmaceutical form of LSD, as a potential treatment for generalized anxiety disorder. A randomized clinical trial published in JAMA found that a single dose reduced anxiety symptoms versus placebo, with benefits persisting up to 12 weeks in the optimal dose group, according to the study and the drug’s sponsor.

OpenAI data shows million weekly suicide talks with ChatGPT

OpenAI has released data indicating that over a million users discuss suicide with ChatGPT each week. The company is addressing these interactions by improving its AI's responses to mental health issues. This comes amid lawsuits and warnings about protecting vulnerable users.

Harvard psychiatrist links brain energy failures to mental illness

In a new interview, Harvard Medical School's Dr. Bruce M. Cohen discusses how disruptions in brain cell energy production may underlie major psychiatric disorders. His research using induced pluripotent stem cells reveals metabolic defects in conditions like schizophrenia and bipolar disorder. The findings advocate for a shift toward biology-based diagnostics and preventive treatments.

Ukrainian crypto trader Konstantin Galich found dead after market crash

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Prominent Ukrainian crypto trader Konstantin Galich, known as Kostya Kudo, was found dead in his Lamborghini on October 11, 2025, amid a severe cryptocurrency market downturn. Authorities suspect suicide but have launched a homicide investigation. His death underscores the emotional toll on traders during volatile periods.

OpenAI plans erotic chats for verified adults starting December

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OpenAI CEO Sam Altman announced that verified adult users will soon be able to engage in erotic conversations with ChatGPT. The change, set for December, includes age verification and new tools to detect mental distress. This follows a history of adjusting content restrictions amid safety concerns.

Skin conditions linked to worse outcomes in early psychosis

Researchers have discovered that individuals experiencing their first episode of psychosis who also have skin issues face higher risks of depression and suicidal thoughts. The finding, presented at the ECNP meeting in Amsterdam, suggests dermatological symptoms could serve as early warning signs for poorer mental health outcomes. This connection may stem from shared developmental origins between the skin and brain.

Scientists identify specific brain cells linked to depression

Researchers at McGill University and the Douglas Institute have pinpointed two types of brain cells altered in people with depression. Using advanced genomic analysis on post-mortem brain tissue, they found genetic disruptions in excitatory neurons and microglia. The findings, published in Nature Genetics, could lead to more targeted treatments for the condition affecting over 264 million people worldwide.

Genes influencing cannabis use identified in genome study

Researchers from UC San Diego and 23andMe have discovered genetic links to cannabis use behaviors, connecting them to over 100 health traits. The study, published on October 13, 2025, in Molecular Psychiatry, highlights two key genes and could inform prevention of cannabis use disorder. It analyzed data from nearly 132,000 participants to explore early-stage risks.

Evolution of human intelligence linked to mental illness vulnerability

Researchers have traced genetic variants in the human genome to reveal that advances in cognitive abilities around 500,000 years ago were soon followed by mutations increasing susceptibility to psychiatric disorders. This suggests a trade-off in brain evolution. The study, published in Cerebral Cortex, analyzed 33,000 genetic variants to build an evolutionary timeline of brain-related traits.

Amnesty International denounces TikTok's failures to European laws

Amnesty International published a report on Tuesday accusing TikTok of exposing young people to toxic content through its algorithms. The NGO estimates that this endangers their mental and physical health. It has seized Arcom for failures to comply with European legal obligations.

 

 

 

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