Keto diet linked to anorexia recovery in small trial

A ketogenic diet helped three in four participants with anorexia nervosa drop below the diagnostic threshold in a small supervised study. Researchers monitored 22 women over 14 weeks at the University of California, San Diego. The findings suggest the approach may ease compulsive food restriction when combined with professional support.

Participants followed a high-fat, low-carbohydrate ketogenic diet under the guidance of a dietitian, psychiatrist and peer counsellor. Eighteen women completed the full period. Thirteen of them showed enough improvement that they no longer met criteria for either anorexia or depression. Guido Frank, the lead researcher, noted that patients often describe their restrictive behaviour as an addiction. He said creating a similar metabolic state while ensuring adequate food intake could reduce that drive. The women remained in a healthy or slightly underweight body-mass range and did not relapse during the study. Sahib Khalsa of the University of California, Los Angeles, cautioned that larger randomised trials are still needed before changing standard treatment practices.

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Illustration of a study participant with brain scans and gut bacteria visuals related to intermittent fasting research.
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Intermittent energy restriction tied to shifts in brain activity and gut microbiome, small study suggests

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A small 2023 study of adults with obesity in China found that an intermittent energy restriction program was associated with weight loss and changes in gut bacteria alongside altered activity in brain regions linked to appetite, cravings and self-control.

An 18-month clinical trial involving more than 200 adults with obesity found that intermittent fasting led to about the same average weight loss as continuous calorie restriction after six months, while participants on the fasting plan reported less need to constantly monitor or restrict their eating.

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Adults with overweight or obesity who limited eating to an eight-hour daily window during a 12-week program maintained more weight loss one year later than participants assigned to eat over 12 hours or more, according to researchers in Spain.

A year-long observational study in Japan suggests that people with type 2 diabetes who tend to overeat in response to tempting food cues such as sight and smell may see greater weight loss—and possibly better blood-sugar improvement—after starting GLP-1 receptor agonists, while those with primarily emotional eating patterns show less consistent links to long-term outcomes.

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Researchers at APC Microbiome Ireland at University College Cork report that early-life exposure to a high-fat, high-sugar diet altered feeding behavior and appetite-related brain pathways in mice into adulthood, even after the animals returned to a standard diet and normal body weight. The team also found that a specific Bifidobacterium strain and a prebiotic fiber mix helped mitigate some of these long-term effects.

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