Arthritis
Personalized foot-angle gait retraining reduced medial knee osteoarthritis pain in sham-controlled trial
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In a randomized, sham-controlled trial, adults with mild-to-moderate medial compartment knee osteoarthritis who were retrained to walk with a personalized, small change in foot progression angle reported greater pain improvement after one year than those given sham retraining. The study, conducted at Stanford University and published in The Lancet Rheumatology, also found a smaller MRI-based worsening of a cartilage microstructure measure in the intervention group.
A minimally invasive procedure known as genicular artery embolization (GAE) was linked to sustained pain reduction and improved function for most people with osteoarthritis-related knee pain in a prospective, single-center study using rapidly resorbable gelatin-based microspheres, with follow-up reported out to 12 months.
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Researchers at Aarhus University report that the hormone GLP-1—mimicked by drugs such as Wegovy—can be measured in the joint fluid of patients with inflammatory arthritis, but only at very low levels. The findings, published in The Lancet Rheumatology, suggest GLP-1–based medicines might eventually be studied for potential direct effects on joint inflammation, though the researchers say clinical trials are needed to show whether such treatment works.