Arthritis
Personalized foot-angle gait retraining reduced medial knee osteoarthritis pain in sham-controlled trial
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In a randomized, sham-controlled trial, adults with mild-to-moderate medial compartment knee osteoarthritis who were retrained to walk with a personalized, small change in foot progression angle reported greater pain improvement after one year than those given sham retraining. The study, conducted at Stanford University and published in The Lancet Rheumatology, also found a smaller MRI-based worsening of a cartilage microstructure measure in the intervention group.
Researchers at Aarhus University report that the hormone GLP-1—mimicked by drugs such as Wegovy—can be measured in the joint fluid of patients with inflammatory arthritis, but only at very low levels. The findings, published in The Lancet Rheumatology, suggest GLP-1–based medicines might eventually be studied for potential direct effects on joint inflammation, though the researchers say clinical trials are needed to show whether such treatment works.
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A major review of 217 clinical trials has identified aerobic exercises like walking, cycling and swimming as the most effective for reducing pain and improving function in knee osteoarthritis. The study, published in The BMJ, recommends these activities as the first-line intervention. Other exercises provide benefits but work best alongside aerobics.
A traditional Brazilian plant known as Joseph's Coat has demonstrated significant anti-inflammatory effects in laboratory studies, potentially offering a new natural treatment for arthritis. Researchers from three Brazilian universities confirmed the plant's ability to reduce swelling and protect joint tissue while showing a safe profile at tested doses. However, further clinical trials are needed before human use.
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A comprehensive review of over 200 studies has determined that aerobic exercises such as walking, cycling, and swimming provide the most effective pain relief and mobility improvements for people with knee osteoarthritis. Published in The BMJ, the analysis emphasizes aerobic activity as the foundation of treatment. All tested exercise types proved safe, with no increased adverse events compared to controls.