Arthritis
Stanford study finds 15-PGDH inhibitor regrew knee cartilage in mice and slowed osteoarthritis changes in human tissue
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Stanford Medicine researchers report that blocking the enzyme 15-PGDH reversed age-related cartilage loss in older mice and reduced osteoarthritis-like damage after ACL-like knee injuries. In lab experiments, cartilage taken from knee replacement surgeries also showed early signs of regeneration after exposure to the inhibitor, findings published in *Science*.
Millions worldwide suffer from osteoarthritis, yet many miss out on the most effective treatment: exercise. Experts highlight that movement nourishes joints and reduces pain more than surgery or medications in many cases. Studies show fewer than half of diagnosed patients receive referrals for physical activity programs.
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Morning stiffness is common after 40 and often harmless. But if it lasts long or comes with swelling and fatigue, it may signal a deeper problem. Doctors advise not ignoring these signs.