Heart Disease
Study links heart benefits of low-carb and low-fat diets to food quality, not macronutrient cuts
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A long-running analysis of nearly 200,000 U.S. health professionals found that both low-carbohydrate and low-fat eating patterns were associated with lower coronary heart disease risk when they emphasized high-quality foods such as whole grains, plant-based sources, and unsaturated fats. Versions of these diets built around refined carbohydrates and animal-based fats and proteins were associated with higher risk, according to a study published in the Journal of the American College of Cardiology (JACC).
Researchers from Mass General Brigham found that the cholesterol drug evolocumab cuts the risk of first-time major cardiovascular events by 31% in high-risk patients with diabetes who lack diagnosed atherosclerosis. The results, from a subgroup analysis of the VESALIUS-CV trial, were presented at the American College of Cardiology's Annual Scientific Session and published in JAMA. Patients on the drug saw LDL cholesterol levels drop significantly alongside standard treatments.
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The American College of Cardiology and American Heart Association have issued new guidelines on cholesterol screening and management, urging earlier testing and personalized risk assessments. The recommendations, presented on March 28 in New Orleans, emphasize lowering LDL cholesterol and incorporating genetic factors like lipoprotein(a). A new risk calculator aims to predict heart disease over longer periods.
A new study from Johns Hopkins Medicine reveals that sex hormones like testosterone and estradiol influence heart disease risk in type 2 diabetes differently for men and women. In men, higher testosterone levels were linked to lower risk, while rising estradiol was associated with higher risk; no such patterns emerged in women. The findings suggest potential for more personalized prevention strategies.
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Two new studies suggest that modest reductions in sodium levels in everyday foods like bread and packaged meals could significantly lower rates of heart disease and stroke in France and the United Kingdom. These changes would occur without requiring people to alter their eating habits. The research highlights the potential for quiet public health improvements through policy and industry collaboration.
Researchers at the University of Sydney have discovered that type 2 diabetes directly alters the heart's structure and energy production, increasing the risk of heart failure. By examining donated human heart tissue, the team identified molecular changes that stiffen the muscle and disrupt cellular function. These findings, published in EMBO Molecular Medicine, highlight a unique profile in patients with both diabetes and ischemic heart disease.
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Binge drinking may feel festive, but cardiologists warn it can quietly damage the heart, trigger dangerous rhythm disorders, raise blood pressure and increase the risk of heart failure and stroke, sometimes within just one night of excess.
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