He Jiankui plans gene editing for Alzheimer’s after prison term

Chinese scientist He Jiankui, who served time in prison for creating the world’s first gene-edited babies, now intends to pursue similar work to combat Alzheimer’s disease. He has criticized Silicon Valley’s efforts in the field as a “Nazi eugenic experiment.” This development revives ethical debates in biotechnology.

In 2018, He Jiankui made headlines by announcing at a scientific conference in Hong Kong that he had produced the world’s first gene-edited babies. The soft-spoken researcher confirmed the reports amid a tense atmosphere in the packed auditorium, adjusting his microphone before addressing the audience.

His actions led to his imprisonment in China for violating regulations on gene editing. Now, years later, He Jiankui is preparing to resume such experiments, this time targeting Alzheimer’s disease with the goal of eradicating it.

He has voiced strong objections to ongoing projects in Silicon Valley, labeling them a “Nazi eugenic experiment.” This perspective underscores the ongoing ethical tensions surrounding gene-editing technologies like CRISPR, which He pioneered in his controversial work.

The announcement, detailed in a recent Wired article, highlights the persistent global divide on the boundaries of genetic intervention. While He’s past work sparked international condemnation for ethical lapses, his renewed ambitions signal a bold push forward in medical applications, though under heightened scrutiny.

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Bootstrap Bio and Manhattan Genomics, biotech firms launched last year to pursue human embryo editing for preventing serious diseases, have closed their doors. The companies cited financial difficulties and internal conflicts as reasons for the shutdowns. The developments highlight challenges in the controversial field of gene-edited babies.

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Researchers in New York have tested an improved gene-editing method on healthy human embryos donated for research. The study shows mixed success in making precise DNA changes while avoiding some unintended mutations.

Three Chinese scientists have been removed from their positions after a whistle-blower raised questions about their research. Nankai University and Sun Yat-sen University announced the decisions.

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Doug Whitney, a US mechanic carrying a genetic mutation that typically triggers early-onset Alzheimer’s disease, has reached his late 70s without symptoms. Researchers link his protection to decades of intense heat exposure in ship engine rooms. The case bolsters evidence that heat therapy may safeguard the brain against the condition.

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