Oncology

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Illustration depicting a self-reinforcing SRSF1–AURKA–MYC molecular circuit in pancreatic cancer cells, disrupted by an antisense oligonucleotide therapy.
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Study maps self-reinforcing SRSF1–AURKA–MYC circuit in pancreatic cancer cells

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Researchers at Cold Spring Harbor Laboratory report they have identified a three-part molecular circuit involving SRSF1, Aurora kinase A (AURKA) and MYC that helps drive aggressive pancreatic ductal adenocarcinoma. In laboratory models, a splice-switching antisense oligonucleotide designed to alter AURKA splicing disrupted the circuit, reducing tumor-cell viability and triggering programmed cell death.

Roche Holding saw its shares drop significantly following the failure of its phase 3 persevERA trial for the breast cancer drug giredestrant to meet its primary endpoint. Despite the setback, the company remains optimistic about the drug's potential in other indications. Analysts view the result as a non-existential hurdle for Roche's broader portfolio.

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The Supreme Federal Court (Stf) unanimously approved an interfederative agreement that redefines the funding of oncology drugs in the Unified Health System (Sus). The decision sets rules for reimbursement by the Union and determines judicial competence for actions related to these treatments. The agreement follows the creation of a new oncology pharmaceutical assistance policy.

Clínica Medilaser in Neiva, Huila, is establishing itself as a regional reference center for comprehensive blood cancer management. Led by Dr. Álvaro Eduardo Mondragón Cardona, the institution provides advanced treatments combining chemotherapy and immunotherapy. This allows patients from southern Colombia to receive specialized care without traveling elsewhere.

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Patients at Port Elizabeth Provincial Hospital in Nelson Mandela Bay are facing renewed shortages of essential chemotherapy drugs, leaving pediatric oncology cases vulnerable. The Eastern Cape Department of Health attributes the issue to a suspended account with a key supplier, with negotiations ongoing to restore supply. This marks the third major stockout this year, highlighting persistent procurement challenges.

A new study showed quantum technology achieving 80% tumor shrinkage in brain cancer, published in The Lancet Oncology on September 11, 2025.

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Summit's new drug for lung cancer demonstrated promising results in recent assessments. This development is part of ongoing biotech advancements in oncology. It was reported alongside other health innovations.

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