Onkologi

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Illustration depicting a self-reinforcing SRSF1–AURKA–MYC molecular circuit in pancreatic cancer cells, disrupted by an antisense oligonucleotide therapy.
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Studie kartlägger självförstärkande SRSF1–AURKA–MYC-krets i pankreascancerceller

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Forskare vid Cold Spring Harbor Laboratory rapporterar att de identifierat en tre-delad molekylär krets som involverar SRSF1, Aurora kinas A (AURKA) och MYC som driver aggressiv pankreasductal adenocarcinom. I laboratoriemodeller bröt en spliceväxlande antisense-oligonukleotid designad för att ändra AURKA-splicing kretsen, minskade tumörcelltvivabilitet och utlöste programmerad celldöd.

An alliance between Clínica Medilaser and the Instituto Médico Oncológico has consolidated an integrated program to treat central nervous system tumors in southern Colombia. The service, led by neurosurgeon Silvia Quintero, serves patients from several regions from its Neiva site.

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One month after the nationwide oncology sanitary alert took effect, Health Minister May Chomali led the signing of a decree transferring $154 billion from the Ministry of Hacienda to the Ministry of Health (Minsal). The funds will exclusively support the Oncology Alert Plan, enhancing public health services' capacity to resolve oncology waiting lists affecting thousands of patients.

Servier Egypt has launched Tibsovo (ivosidenib), the first targeted therapy available in the country for patients with IDH1-mutated Acute Myeloid Leukemia (AML) and intrahepatic cholangiocarcinoma. The treatment offers a median overall survival of 29.3 months for eligible AML patients and 10.3 months for those with intrahepatic cholangiocarcinoma, according to clinical data. It is approved as a first-line treatment for AML and a second-line option for intrahepatic cholangiocarcinoma.

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Oncologist Paulo Hoff warned that excessive sun exposure is the most common cause of cancer, particularly non-melanoma skin cancer. In a course on CasaFolha, he emphasizes the importance of prevention and early diagnosis to boost cure rates. Hoff recommends avoiding the sun between 10am and 2pm and using sunscreen.

En kombination av enzalutamid och hormonbehandling har minskat risken för död med mer än 40 % hos män med återkommande prostatacancer, enligt en stor klinisk prövning. Studien, som involverade över 1 000 patienter världen över, leddes av forskare vid Cedars-Sinai och presenterades vid en medicinsk kongress i Berlin. Experter beskriver resultaten som en spelomvältnare för behandling av aggressiva fall.

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Researchers at Spain's National Cancer Research Centre (CNIO) have developed a comprehensive catalog of mutational 'scars' in DNA caused by cancer. This breakthrough, published in Nature, could help bypass resistances to treatments like PARP inhibitors. The study analyzes thousands of tumor samples to identify key genetic patterns.

 

 

 

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