腫瘍学
膵臓がん細胞における自己強化型SRSF1–AURKA–MYC回路を研究がマッピング
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Cold Spring Harbor Laboratoryの研究者らが、SRSF1、オーロラキナーゼA（AURKA）、MYCを介した3要素の分子回路を同定し、これが攻撃的な膵管腺がんを駆動することを報告。実験室モデルでは、AURKAのスプライシングを変化させるスプライススイッチングアンチセンスオリゴヌクレオチド（ASO）がこの回路を阻害し、腫瘍細胞の生存性を低下させ、プログラム細胞死を誘導した。
An alliance between Clínica Medilaser and the Instituto Médico Oncológico has consolidated an integrated program to treat central nervous system tumors in southern Colombia. The service, led by neurosurgeon Silvia Quintero, serves patients from several regions from its Neiva site.
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One month after the nationwide oncology sanitary alert took effect, Health Minister May Chomali led the signing of a decree transferring $154 billion from the Ministry of Hacienda to the Ministry of Health (Minsal). The funds will exclusively support the Oncology Alert Plan, enhancing public health services' capacity to resolve oncology waiting lists affecting thousands of patients.
Servier Egypt has launched Tibsovo (ivosidenib), the first targeted therapy available in the country for patients with IDH1-mutated Acute Myeloid Leukemia (AML) and intrahepatic cholangiocarcinoma. The treatment offers a median overall survival of 29.3 months for eligible AML patients and 10.3 months for those with intrahepatic cholangiocarcinoma, according to clinical data. It is approved as a first-line treatment for AML and a second-line option for intrahepatic cholangiocarcinoma.
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Oncologist Paulo Hoff warned that excessive sun exposure is the most common cause of cancer, particularly non-melanoma skin cancer. In a course on CasaFolha, he emphasizes the importance of prevention and early diagnosis to boost cure rates. Hoff recommends avoiding the sun between 10am and 2pm and using sunscreen.
エンザルタミドとホルモン療法の組み合わせが、再発前立腺がんの男性の死亡リスクを40%以上低減したという大規模臨床試験の結果です。この研究は、世界中の1,000人以上の患者を対象とし、Cedars-Sinaiの研究者らが主導し、ベルリンの医学大会で発表されました。専門家はこの発見を攻撃的な症例の治療におけるゲームチェンジャーと形容しています。
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Researchers at Spain's National Cancer Research Centre (CNIO) have developed a comprehensive catalog of mutational 'scars' in DNA caused by cancer. This breakthrough, published in Nature, could help bypass resistances to treatments like PARP inhibitors. The study analyzes thousands of tumor samples to identify key genetic patterns.
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