Brain waves may restore movement in paralyzed patients

Researchers have developed a noninvasive method using EEG brain scans to detect movement intentions in people with spinal cord injuries. By capturing signals from the brain and potentially routing them to spinal stimulators, the approach aims to bypass damaged nerves. While promising, the technology still struggles with precise control, especially for lower limbs.

People with spinal cord injuries often retain healthy nerves in their limbs and a functioning brain, but damage to the spinal cord interrupts the signals that enable movement. A new study explores using electroencephalography (EEG) to detect these brain signals and restore communication without invasive surgery.

Published in APL Bioengineering by AIP Publishing, the research involves scientists from universities in Italy and Switzerland. The team tested EEG caps, which record brain activity from the scalp, on patients attempting simple movements. Unlike implanted electrodes, EEG avoids surgical risks. "It can cause infections; it's another surgical procedure," said author Laura Toni. "We were wondering whether that could be avoided."

The study focused on decoding signals for lower-limb movements, which originate deeper in the brain and are harder to capture. "The brain controls lower limb movements mainly in the central area, while upper limb movements are more on the outside," Toni explained. "It's easier to have a spatial mapping of what you're trying to decode compared to the lower limbs."

A machine learning algorithm analyzed the EEG data, successfully distinguishing attempts to move from stillness but struggling to differentiate specific actions. The researchers plan to refine the system to recognize intentions like standing or walking and integrate it with spinal cord stimulators. If improved, this could enable paralyzed individuals to regain meaningful mobility through brain-driven nerve activation.

The work builds on prior invasive methods, offering a safer alternative. Lead authors include Laura Toni, Valeria De Seta, Luigi Albano, and others, with the full study titled "Decoding lower-limb movement attempts from electro-encephalographic signals in spinal cord injury patients," published in 2026.

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University of Sydney researchers examine a detailed fMRI brain scan highlighting pain-control areas in the brainstem, symbolizing advances in non-opioid pain treatments.
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Scientists map brainstem’s pain‑control network, pointing to targeted non‑opioid relief

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Using 7‑Tesla fMRI and a placebo paradigm, University of Sydney researchers mapped how the human brainstem modulates pain by body region. The study, published in Science on August 28, 2025, outlines a somatotopic system centered on the periaqueductal gray and rostral ventromedial medulla and suggests avenues for localized, non‑opioid treatments.

Scientists at Brown University have identified a subtle brain activity pattern that can forecast Alzheimer's disease in people with mild cognitive impairment up to two and a half years in advance. Using magnetoencephalography and a custom analysis tool, the researchers detected changes in neuronal electrical signals linked to memory processing. This noninvasive approach offers a potential new biomarker for early detection.

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Two Chinese patients with high-level paralysis have successfully used brain-machine interface (BMI) technology to control a power wheelchair, direct a robotic dog to retrieve deliveries, and operate a robotic arm to grasp a cup and drink water using only their thoughts. The achievements were announced on Wednesday at a media briefing by the Center for Excellence in Brain Science and Intelligence Technology of the Chinese Academy of Sciences in Shanghai. This marks a major advancement toward practical clinical applications of BMI.

Researchers at the University of California, Riverside, have identified how inflammation in multiple sclerosis disrupts mitochondrial function in the brain, leading to the loss of key neurons that control balance and coordination. Published in the Proceedings of the National Academy of Sciences, the findings highlight a potential pathway for new treatments to preserve mobility in the 2.3 million people affected by the disease worldwide. The study examined human brain tissue and a mouse model to trace these energy failures over time.

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Researchers have developed a new bioluminescent imaging tool that allows neurons to glow from within, enabling real-time observation of brain activity without external lasers. This innovation, called CaBLAM, overcomes limitations of traditional fluorescence methods by providing clearer, longer-lasting recordings in living animals. The tool promises deeper insights into neural function and potential applications beyond the brain.

Scientists at Tulane University and collaborating institutions have found that neurons release an enzyme called vertebrate lonesome kinase (VLK) outside cells to help switch on pain signals after injury. Removing VLK from pain-sensing neurons in mice sharply reduced post-surgical pain–like responses without impairing normal movement or basic sensation, according to a study in Science, suggesting a potential new route to more targeted pain treatments.

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Researchers have engineered a protein that detects subtle glutamate signals between neurons, unveiling a previously hidden aspect of brain communication. This tool allows real-time observation of how brain cells process incoming information, potentially advancing studies on learning, memory, and neurological disorders. The findings, published in Nature Methods, highlight a breakthrough in neuroscience.

 

 

 

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