Brain protein decline linked to aging in mice study

A 2023 study found that falling levels of the protein Menin in the hypothalamus drive multiple signs of aging in mice. Restoring the protein or supplementing with the amino acid D-serine improved memory and other measures.

Researchers at Xiamen University in China showed that Menin levels drop sharply in a specific part of the hypothalamus as mice age. When they lowered Menin in younger animals, the mice developed brain inflammation, weaker bones, thinner skin, poorer balance, memory loss, and shorter lifespans.

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Split-scene illustration of UCSF mouse study: older mouse struggles in maze with poor hippocampal neural links due to FTL1; treated mouse excels with enhanced connections.
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UCSF study links iron-associated protein FTL1 to age-related memory decline in mice

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Researchers at the University of California, San Francisco report that higher levels of the iron-associated protein FTL1 in the hippocampus of older mice are tied to weaker neural connections and worse performance on cognitive tests. In the experiments, reducing FTL1 in older mice was associated with increased neuronal connectivity and improved memory performance, findings published in Nature Aging.

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Building on genomic research linking Alzheimer's origins to inflammation in peripheral tissues like the gut, lungs, or skin, practical lifestyle measures can help curb chronic inflammation. These include vaccination, oral hygiene, diet, exercise, weight control, and stress management, offering benefits for overall health amid evolving science.

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