Penurunan protein otak dikaitkan dengan penuaan dalam studi pada tikus

Sebuah studi tahun 2023 menemukan bahwa penurunan kadar protein Menin di hipotalamus memicu berbagai tanda penuaan pada tikus. Memulihkan protein tersebut atau memberikan suplemen asam amino D-serine terbukti meningkatkan memori dan indikator kesehatan lainnya.

Para peneliti di Xiamen University, Tiongkok, menunjukkan bahwa kadar Menin menurun secara drastis di bagian tertentu hipotalamus seiring bertambahnya usia tikus. Ketika kadar Menin diturunkan pada hewan yang lebih muda, tikus-tikus tersebut mengalami peradangan otak, tulang yang lebih lemah, kulit yang lebih tipis, keseimbangan yang buruk, penurunan daya ingat, dan masa hidup yang lebih pendek.

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Split-scene illustration of UCSF mouse study: older mouse struggles in maze with poor hippocampal neural links due to FTL1; treated mouse excels with enhanced connections.
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UCSF study links iron-associated protein FTL1 to age-related memory decline in mice

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Researchers at the University of California, San Francisco report that higher levels of the iron-associated protein FTL1 in the hippocampus of older mice are tied to weaker neural connections and worse performance on cognitive tests. In the experiments, reducing FTL1 in older mice was associated with increased neuronal connectivity and improved memory performance, findings published in Nature Aging.

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