2023年の研究により、マウスの視床下部におけるタンパク質「メニン（Menin）」のレベル低下が、老化の兆候を複数引き起こしていることが明らかになった。このタンパク質を回復させるか、アミノ酸のD-セリンを補給することで、記憶力やその他の健康指標が改善した。
中国の厦門大学の研究者らは、マウスが老化するにつれて視床下部の特定の部位においてメニンのレベルが急激に低下することを明らかにした。若いマウスでメニンを減少させたところ、脳の炎症、骨の脆弱化、皮膚の薄化、バランス能力の低下、記憶喪失、そして寿命の短縮といった症状が確認された。
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A study from the Buck Institute for Research on Aging reports that the APOE2 variant—long associated with lower Alzheimer’s risk and exceptional longevity—helps human neurons better withstand DNA damage and resist a senescent, dysfunctional state. The work, published in the journal Aging Cell, used engineered human stem-cell–derived neurons and mouse models to explore how common APOE gene forms may influence cellular stress responses.
Researchers have identified declining levels of phosphatidylcholine as a key driver of age-related mitochondrial dysfunction. The discovery, made at the Leibniz Institute on Aging in Germany, shows that boosting this lipid can restore youthful mitochondrial function in laboratory models.
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A modified Mediterranean-style diet low in protein but supplemented with methionine helped older mice stay healthier while eating more food. Researchers at the University of Southern California led the study, which also drew on human data linking lower animal protein intake to reduced obesity and diabetes rates. The findings were published in Cell Metabolism.
Researchers at Texas A&M University have developed a nasal spray that appears to reverse aspects of brain aging after just two doses. The treatment reduced inflammation and restored memory function in models for months afterward. The findings were published in the Journal of Extracellular Vesicles.
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Japanese researchers have identified a new seed of the amyloid beta protein. The discovery could lead to early-stage therapy for the neurodegenerative disease.