2023年の研究により、マウスの視床下部におけるタンパク質「メニン（Menin）」のレベル低下が、老化の兆候を複数引き起こしていることが明らかになった。このタンパク質を回復させるか、アミノ酸のD-セリンを補給することで、記憶力やその他の健康指標が改善した。
中国の厦門大学の研究者らは、マウスが老化するにつれて視床下部の特定の部位においてメニンのレベルが急激に低下することを明らかにした。若いマウスでメニンを減少させたところ、脳の炎症、骨の脆弱化、皮膚の薄化、バランス能力の低下、記憶喪失、そして寿命の短縮といった症状が確認された。
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Researchers at the University of California, San Francisco report that higher levels of the iron-associated protein FTL1 in the hippocampus of older mice are tied to weaker neural connections and worse performance on cognitive tests. In the experiments, reducing FTL1 in older mice was associated with increased neuronal connectivity and improved memory performance, findings published in Nature Aging.
A team of researchers led by Professor Yan-Jiang Wang has published a review arguing that Alzheimer's disease requires integrated treatments targeting multiple factors, not single causes. New drugs like lecanemab and donanemab offer modest benefits by slowing decline, but fall short of reversal. The paper, in Science China Life Sciences, emphasizes genetics, aging, and systemic health alongside amyloid-beta and tau proteins.
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Researchers at Cold Spring Harbor Laboratory have found that blocking the protein PTP1B improves memory and boosts plaque clearance in mouse models of Alzheimer's disease. The discovery links the protein to brain immune function and metabolic risks like diabetes and obesity. The team aims to develop inhibitors for potential human treatments.
Researchers at Texas Children’s Hospital’s Duncan Neurological Research Institute and Baylor College of Medicine report an experimental gene-targeting approach designed to increase levels of the MeCP2 protein disrupted in Rett syndrome. In mouse experiments and neurons derived from patient cells, the strategy boosted MeCP2 and partially restored cellular structure, electrical activity and gene-expression patterns, according to findings published in Science Translational Medicine.
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Building on genomic research linking Alzheimer's origins to inflammation in peripheral tissues like the gut, lungs, or skin, practical lifestyle measures can help curb chronic inflammation. These include vaccination, oral hygiene, diet, exercise, weight control, and stress management, offering benefits for overall health amid evolving science.