دراسة على الفئران تربط بين تراجع بروتين دماغي والشيخوخة

24 مايو، 2026

من إعداد الذكاء الاصطناعي

كشفت دراسة أجريت عام 2023 أن انخفاض مستويات بروتين "مينين" في منطقة تحت المهاد يؤدي إلى ظهور علامات متعددة للشيخوخة لدى الفئران. وقد أدى استعادة هذا البروتين أو تناول مكملات الحمض الأميني "دي-سيرين" إلى تحسين الذاكرة ومؤشرات أخرى.

أظهر باحثون في جامعة شيامن بالصين أن مستويات بروتين "مينين" تنخفض بشكل حاد في جزء معين من منطقة تحت المهاد مع تقدم الفئران في العمر. وعندما قام الباحثون بخفض مستويات هذا البروتين لدى الفئران الأصغر سناً، عانت تلك الفئران من التهابات في الدماغ، وضعف في العظام، وترقق في الجلد، وتدهور في التوازن، وفقدان في الذاكرة، وقصر في العمر الافتراضي.

Study links APOE2 variant to stronger DNA repair and reduced cellular aging in human neurons

24 يوليو، 2026 من إعداد الذكاء الاصطناعي صورة مولدة بواسطة الذكاء الاصطناعي تم التحقق من الحقائق

A study from the Buck Institute for Research on Aging reports that the APOE2 variant—long associated with lower Alzheimer’s risk and exceptional longevity—helps human neurons better withstand DNA damage and resist a senescent, dysfunctional state. The work, published in the journal Aging Cell, used engineered human stem-cell–derived neurons and mouse models to explore how common APOE gene forms may influence cellular stress responses.

Scientists find reversible trigger for mitochondrial aging

Researchers have identified declining levels of phosphatidylcholine as a key driver of age-related mitochondrial dysfunction. The discovery, made at the Leibniz Institute on Aging in Germany, shows that boosting this lipid can restore youthful mitochondrial function in laboratory models.

Longevity diet cuts fat and frailty in aging mice

10 يوليو، 2026 من إعداد الذكاء الاصطناعي

A modified Mediterranean-style diet low in protein but supplemented with methionine helped older mice stay healthier while eating more food. Researchers at the University of Southern California led the study, which also drew on human data linking lower animal protein intake to reduced obesity and diabetes rates. The findings were published in Cell Metabolism.

Health

Study identifies gene that exercise targets to reverse muscle aging

Health

Speed training game alters amyloid levels in men's brains

Health

SORLA protein found to shield brain from Alzheimer’s tau damage

Texas A&M nasal spray reverses brain aging in study

Researchers at Texas A&M University have developed a nasal spray that appears to reverse aspects of brain aging after just two doses. The treatment reduced inflammation and restored memory function in models for months afterward. The findings were published in the Journal of Extracellular Vesicles.

Japan scientists identify clusters of protein believed to trigger Alzheimer’s disease

21 يوليو، 2026 من إعداد الذكاء الاصطناعي

Japanese researchers have identified a new seed of the amyloid beta protein. The discovery could lead to early-stage therapy for the neurodegenerative disease.

20 يوليو 2026 11:36

دراسة على الفئران تربط بين تراجع بروتين دماغي والشيخوخة

مقالات ذات صلة

Study links APOE2 variant to stronger DNA repair and reduced cellular aging in human neurons

Scientists find reversible trigger for mitochondrial aging

Longevity diet cuts fat and frailty in aging mice

Study identifies gene that exercise targets to reverse muscle aging

Speed training game alters amyloid levels in men's brains

SORLA protein found to shield brain from Alzheimer’s tau damage

Texas A&M nasal spray reverses brain aging in study

Japan scientists identify clusters of protein believed to trigger Alzheimer’s disease

University of Kentucky study links microglia to sleep loss in Alzheimer’s-model mice

Drug restores senescent cell clearance in aging mice

Tau protein found essential for forming lasting memories

Anti-aging drug combo damages myelin in mouse brains

Nanoparticles reduced amyloid-β and improved cognition in an Alzheimer’s mouse model, researchers report

Scientists restore memory in Alzheimer's mice by blocking PTP1B

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