Studi temukan faktor risiko Alzheimer berdampak lebih parah pada perempuan

Penelitian baru dari University of California San Diego menunjukkan bahwa beberapa faktor risiko umum demensia memengaruhi kinerja kognitif perempuan lebih kuat dibandingkan laki-laki. Temuan ini membantu menjelaskan mengapa perempuan menyumbang hampir dua pertiga kasus Alzheimer di Amerika Serikat.

Para ilmuwan menganalisis data dari lebih dari 17.000 orang dewasa paruh baya dan lanjut usia dalam Health and Retirement Study. Mereka meneliti 13 faktor risiko yang telah mapan, termasuk hipertensi, diabetes, depresi, kurangnya aktivitas fisik, dan gangguan pendengaran. Hasil penelitian tersebut diterbitkan pada 19 Mei di jurnal Biology of Sex Differences.

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Illustration depicting projected increases in cardiovascular risks like high blood pressure, obesity, and diabetes among diverse U.S. women by 2050.
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AHA scientific statement projects rising cardiovascular risk factors for U.S. women by 2050

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A new American Heart Association scientific statement published Feb. 25, 2026 in Circulation projects that cardiovascular risk factors such as high blood pressure, obesity and diabetes will become more common among U.S. women by 2050, with particularly steep increases forecast for some younger women and for several racial and ethnic groups.

Women maintain normal scores on standard memory tests for nearly three years longer than men even after Alzheimer’s-related brain changes begin. This cognitive advantage can mask early signs of the disease and delay treatment. A new analysis of long-term studies in the US and Canada highlights the issue.

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People who reported more mentally stimulating experiences from childhood through older age were less likely to develop Alzheimer’s disease and tended to develop symptoms years later than peers with the lowest enrichment, according to an observational study published in Neurology.

A new study has found that adults with higher vitamin D levels in their 30s and 40s tend to have lower levels of tau protein in their brains about 16 years later. Tau is a key biomarker associated with dementia. The research, published this week, highlights a potential modifiable risk factor for brain health.

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