Studi kaitkan obat GLP-1 dengan penurunan risiko kanker payudara

Dalam sebuah studi observasional berskala besar, wanita yang mengonsumsi obat GLP-1 seperti Ozempic dan Wegovy menunjukkan kemungkinan terkena kanker payudara sekitar 30 persen lebih rendah.

Para peneliti meninjau rekam medis elektronik dari lebih dari 111.000 wanita berusia 45 hingga 80 tahun dengan indeks massa tubuh 25 atau lebih yang menjalani pencitraan payudara di Penn Medicine antara Januari 2022 dan Juni 2025. Mereka yang diresepkan obat GLP-1 memiliki kemungkinan terkena kanker payudara 35,1 persen lebih rendah pada kelompok penuh dan 30,5 persen lebih rendah dalam analisis yang disesuaikan. Temuan tersebut dipresentasikan pada Pertemuan Tahunan American Society of Clinical Oncology 2026 dan diterbitkan dalam JCO Oncology Practice. Elizabeth McDonald, seorang profesor di Perelman School of Medicine, University of Pennsylvania, mencatat bahwa studi tersebut bersifat observasional dan tidak membuktikan hubungan sebab akibat. McDonald dan rekan-rekannya berencana untuk meluncurkan uji klinis guna menguji apakah obat GLP-1 dapat membantu mencegah kanker payudara pada wanita berisiko tinggi. Obat-obatan tersebut memengaruhi jalur yang terkait dengan perkembangan kanker, meskipun penurunan berat badan juga dapat berkontribusi terhadap manfaat yang teramati.

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Realistic illustration contrasting social stigma: neutral for overweight, positive for exercise weight loss, negative for Ozempic users.
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Study finds people who use Ozempic-like drugs for weight loss face added stigma

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People who lose weight using GLP-1 medications such as Ozempic and Wegovy may be judged more negatively than those who lose weight through diet and exercise — and even more negatively than people who do not lose weight at all — according to a new study led by Rice University psychologist Erin Standen.

GLP-1 medications such as Ozempic, Wegovy and Zepbound deliver strong health value but create massive budget pressures for insurers. Researchers from the University of Mississippi highlight the gap between cost-effectiveness and affordability. Coverage remains restricted for many eligible patients.

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A large study tracking nearly 100,000 people in Sweden found that GLP-1 receptor agonists like semaglutide, sold as Ozempic and Wegovy, are associated with significantly fewer psychiatric hospital visits and reduced sick days due to mental health issues. Researchers observed drops of up to 47% in various mental health risks during drug use periods. The findings appear in The Lancet Psychiatry.

A new analysis of patient records shows that adults with type 2 diabetes who take GLP-1 receptor agonists face a higher rate of alopecia than those on other common diabetes medications.

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A year-long observational study in Japan suggests that people with type 2 diabetes who tend to overeat in response to tempting food cues such as sight and smell may see greater weight loss—and possibly better blood-sugar improvement—after starting GLP-1 receptor agonists, while those with primarily emotional eating patterns show less consistent links to long-term outcomes.

Semaglutide, the active ingredient in Ozempic and Wegovy, was associated with slower changes in DNA methylation–based “epigenetic clocks” in adults living with HIV in a post hoc analysis of a randomized, placebo-controlled trial. Scientists say larger studies are needed to determine whether these molecular signals translate into meaningful long-term health benefits.

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