Estudo associa medicamentos GLP-1 a menor risco de câncer de mama

Mulheres que tomam medicamentos GLP-1, como Ozempic e Wegovy, apresentaram cerca de 30% menos chances de desenvolver câncer de mama em um grande estudo observacional.

Pesquisadores analisaram registros eletrônicos de saúde de mais de 111.000 mulheres com idades entre 45 e 80 anos, com índice de massa corporal igual ou superior a 25, que realizaram exames de imagem das mamas na Penn Medicine entre janeiro de 2022 e junho de 2025. Aquelas que receberam prescrição de medicamentos GLP-1 tiveram chances 35,1% menores de câncer de mama no grupo total e 30,5% menores em uma análise pareada. As descobertas foram apresentadas na Reunião Anual da Sociedade Americana de Oncologia Clínica de 2026 e publicadas na JCO Oncology Practice. Elizabeth McDonald, professora da Perelman School of Medicine da Universidade da Pensilvânia, observou que o estudo foi observacional e não comprova causalidade. McDonald e seus colegas planejam iniciar ensaios clínicos para testar se os medicamentos GLP-1 podem ajudar a prevenir o câncer de mama em mulheres de alto risco. Os medicamentos afetam vias ligadas ao desenvolvimento do câncer, embora a perda de peso também possa contribuir para o benefício observado.

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Realistic illustration contrasting social stigma: neutral for overweight, positive for exercise weight loss, negative for Ozempic users.
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Study finds people who use Ozempic-like drugs for weight loss face added stigma

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People who lose weight using GLP-1 medications such as Ozempic and Wegovy may be judged more negatively than those who lose weight through diet and exercise — and even more negatively than people who do not lose weight at all — according to a new study led by Rice University psychologist Erin Standen.

A large study tracking nearly 100,000 people in Sweden found that GLP-1 receptor agonists like semaglutide, sold as Ozempic and Wegovy, are associated with significantly fewer psychiatric hospital visits and reduced sick days due to mental health issues. Researchers observed drops of up to 47% in various mental health risks during drug use periods. The findings appear in The Lancet Psychiatry.

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A large review of cardiovascular outcome trials found that people taking GLP-1 receptor agonists—drugs that include semaglutide (sold as Ozempic)—had a lower risk of major heart-related events than those given placebo. The analysis pooled results from 11 trials involving more than 90,000 participants, with an average follow-up of nearly three years, and reported benefits across patient subgroups including those with and without diabetes.

Teddi Mellencamp, the Real Housewives of Beverly Hills alum, spilled on her podcast that she begged her doctor for GLP-1 weight-loss drugs while battling cancer. She gained weight from steroids but got shut down. Joking about the irony, she quipped about living her best life without the meds.

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The US Food and Drug Administration approved Foundayo, a new once-daily pill for obesity treatment, on Wednesday. Eli Lilly, the manufacturer, also produces the weight-loss injection Zepbound. The approval positions Foundayo as the second obesity pill cleared by the FDA.

Researchers at Vanderbilt Health discovered that both popular weight loss drugs and bariatric surgery significantly reduce fat mass while causing modest losses in fat-free mass, including muscle, in patients with obesity. The findings, based on over 3,000 patients, show improvements in overall body composition over 24 months. Maintaining this balance is crucial for long-term health, the study emphasizes.

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