Researchers doubt reliability of microplastics studies in human body

Several studies on microplastics in the human body are being criticized by experts as unreliable. The reported quantities are often exaggerated and based on methodological errors. Critics warn of misinterpretations that could influence policy decisions.

For years, studies have detected alarming amounts of micro- and nanoplastics in organs such as brains, arteries, placentas, and testicles, drawing global attention. Now these findings are under scrutiny: Experts argue in the British newspaper Guardian that many discoveries may stem from contaminations, inaccuracies, and misinterpretations. While plastic pollution is undeniably ubiquitous, detecting tiny particles pushes the limits of analytical technology.

Seven studies have been publicly questioned, with another review identifying 18 investigations marred by scientific inaccuracies. For instance, particles were detected that turned out to be natural body substances. A particularly contested study from February 2025 reported a sharp rise in microplastics in the brain. Dr. Dušan Materić from Germany's Helmholtz Centre for Environmental Research called it a 'joke' in the Guardian, pointing to misinterpretations from fat tissue mimicking polyethylene signals.

Similar accusations target research on plastics in arteries, male reproductive organs, blood samples, and nanoplastics in mineral water, where 100,000 particles per liter were deemed 'grossly unreliable.' The common Py-GC-MS method is faulted for confusing polyethylene and PVC with fat components. Environmental chemist Cassandra Rauert from the University of Queensland stated: 'It's a problem in the entire research field. Many of the reported concentrations are completely unrealistic.'

Germany's Deutsches Ärzteblatt had raised similar concerns in July, noting a lack of reliable data on distribution in the body. Authors of the criticized studies defend their work: The field is nascent, improvements are underway, and potential inaccuracies were addressed. These doubts reopen questions about actual exposure levels and health consequences, potentially complicating regulations or benefiting industry arguments.

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Illustration depicting microplastics accelerating atherosclerosis in male mice, contrasting with unaffected female mice, in a UC Riverside lab setting.
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Microplastics accelerate atherosclerosis in male mice, UC Riverside–led study finds

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A University of California, Riverside team reports that everyday microplastic exposure sped the buildup of arterial plaque in male—but not female—mice, pointing to possible sex-specific cardiovascular risks and endothelial cell vulnerability. The effects occurred without changes in body weight or cholesterol.

Researchers have discovered far higher levels of microplastics and nanoplastics in city air than previously estimated, highlighting the atmosphere as a key pathway for plastic pollution. Using a new automated technique, scientists in China measured these tiny particles in Guangzhou and Xi'an, revealing concentrations two to six orders of magnitude above earlier reports. Road dust and rainfall significantly influence how these plastics move through the air.

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A new study reveals that microplastics are disrupting the ocean's vital role in absorbing carbon dioxide, potentially exacerbating global warming. Researchers highlight how these tiny particles interfere with marine organisms and release greenhouse gases. The findings call for urgent global action to address plastic pollution alongside climate efforts.

Researchers in Brazil have found dangerous levels of toxic metals such as barium and lead in popular plastic toys, with many products exceeding national and European safety limits. The study, which analyzed 70 toys sold in one major city, warns that even small amounts released during mouthing may pose health risks and calls for tighter regulation and oversight.

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A Rutgers University chemist has developed a new type of plastic that mimics natural polymers to break down on demand, potentially reducing environmental pollution. Inspired by plastic waste during a hike, Yuwei Gu's team engineered materials that degrade under everyday conditions without harsh treatments. The breakthrough, detailed in Nature Chemistry, allows precise control over breakdown times from days to years.

Researchers have discovered that common food emulsifiers consumed by mother mice can disrupt their offspring's gut microbiome from early life, increasing risks of inflammation, gut disorders, and obesity later on. The study, conducted at Institut Pasteur and Inserm, highlights potential generational health impacts without direct exposure. Findings were published in Nature Communications.

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A Cell Press review published on November 5, 2025, highlights tiny camelid-derived antibodies known as nanobodies as potential tools for treating conditions such as Alzheimer’s disease and schizophrenia. The authors say these proteins can reach brain targets in mice more readily than conventional antibodies and outline key steps before human testing.

 

 

 

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