Cholesterol
Randomized trial finds certain processed hard fats did not worsen short-term heart risk markers
Heather Vogel AI에 의해 생성된 이미지 사실 확인됨
A small randomized crossover study found no meaningful differences in cholesterol or other short‑term cardiometabolic markers when healthy adults consumed either palmitic‑rich or stearic‑rich interesterified fats for six weeks apiece.
Genetic study links lower cholesterol to reduced dementia risk
Heather Vogel 사실 확인됨
A large-scale genetic analysis of about 1.09 million people suggests that lifelong, genetically lower cholesterol—specifically non‑HDL cholesterol—is associated with substantially reduced dementia risk. Using Mendelian randomization to emulate the effects of cholesterol‑lowering drug targets such as those for statins (HMGCR) and ezetimibe (NPC1L1), the study found up to an approximately 80% lower risk per 1 mmol/L reduction for some targets. ([research-information.bris.ac.uk](https://research-information.bris.ac.uk/en/publications/cholesterollowering-drug-targets-reduce-risk-of-dementia-mendelia?utm_source=openai))
New DNA-based therapy reduces cholesterol by nearly 50 percent
Researchers from the University of Barcelona and the University of Oregon have developed a DNA-based treatment that targets the PCSK9 gene to lower cholesterol levels without the side effects of statins. Using polypurine hairpins, the therapy increases cholesterol uptake by cells and reduces artery-clogging lipids in animal models. The findings, published in Biochemical Pharmacology, suggest a safer alternative for preventing cardiovascular diseases.