Combinação de medicamentos antienvelhecimento danifica a mielina no cérebro de camundongos

Um tratamento antienvelhecimento amplamente estudado provocou danos cerebrais significativos em camundongos, de acordo com uma nova pesquisa da Universidade de Connecticut. A combinação dos medicamentos dasatinibe e quercetina causou perda de mielina e alterações semelhantes às observadas na esclerose múltipla. As descobertas levantam questões sobre seu uso em estudos de longevidade e terapias off-label.

Pesquisadores da Universidade de Connecticut testaram a combinação de dasatinibe e quercetina em camundongos jovens e velhos. Eles descobriram que o tratamento reduziu as camadas protetoras de mielina ao redor das fibras nervosas no cérebro, com os animais mais jovens apresentando danos maiores do que os mais velhos. O corpo caloso também se deteriorou nos camundongos tratados, produzindo efeitos semelhantes aos descritos como 'cérebro de quimioterapia' em humanos submetidos ao tratamento quimioterápico.

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