Personal health risk assessment reveals modifiable cancer risks

Katie Wells, founder of Wellness Mama, shares insights from her personalized health risk assessment using AI-driven tools, highlighting how lifestyle factors can significantly influence chronic disease risks. The assessment, powered by data from over 10,000 studies, showed her cancer risk below the population average despite family history. It underscores a shift toward proactive prevention over reactive medicine.

Chronic diseases such as heart disease, cancer, metabolic conditions like type 2 diabetes, and Alzheimer’s dementia—often called the 'four horsemen'—account for about 85% of deaths in people over 50, with rates rising even among younger adults and children. These illnesses develop gradually over years or decades, driven by lifestyle choices, environmental exposures, and biological shifts, yet traditional medicine largely reacts after symptoms appear rather than preventing them early.

Wells recounts her own experience with undiagnosed hypothyroid symptoms for years, illustrating how subtle early signals are often missed. Standard screenings fall short: heart disease risk models focus on a narrow 10-year window, cancer risk is rarely assessed routinely for average individuals, and Alzheimer’s evaluation typically waits for symptoms, which can emerge 20 to 30 years after onset.

Advancements in AI and data analysis are transforming this landscape. Tools like those from Catch analyze hundreds of variables from thousands of studies to produce personalized lifetime cancer risk profiles, identifying key influencers and actionable changes. Wells's assessment revealed that factors like having children at a younger age, multiple pregnancies, and breastfeeding lowered her breast and uterine cancer risks. Her blood type slightly elevated risks for some cancers, while her height marginally increased it, offset by physical activity.

Practical recommendations included boosting intake of vegetables—especially fermented and colorful ones—and oily fish weekly, linked to reduced risks of multiple cancers, including stomach and lung types. Surprising links emerged too: regular coffee consumption correlates with lower risks for several cancers, and a history of asthma or allergies may protect against certain brain cancers. Conversely, head injuries, radon exposure, poor sleep, and indoor air pollution heighten risks.

Wells emphasizes that 60 to 90% of disease risk is modifiable, with less than 10% of cancer risk purely genetic. Early detection dramatically improves outcomes, such as pushing cancer survival rates near 90% when caught promptly. She applies similar principles to heart disease, noting that cholesterol alone misses factors like inflammation and light exposure, and to Alzheimer’s, where lifestyle drives risk decades before symptoms.

While praising the tool's nuance, Wells diverges on sun exposure, arguing moderate, non-burning sunlight supports vitamin D levels and overall health without clear skin cancer links, prioritizing personal discernment alongside data.

Связанные статьи

Illustration of animals affected by chronic diseases, with a scientist analyzing shared human-animal health risks in a lab setting.
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Study maps rise of chronic diseases in animals and shared drivers with humans

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Animals across pets, livestock, wildlife and aquaculture are increasingly affected by chronic illnesses long associated with people. A Risk Analysis paper led by the Agricultural University of Athens outlines an integrated model to monitor and manage these conditions across species.

A large study indicates that tailoring breast cancer screening to individual risk factors is safer and more effective than routine annual mammograms for all women. Researchers from the WISDOM study analyzed data from 46,000 participants and found reduced rates of advanced cancers without compromising safety. The approach incorporates genetics, health history, and lifestyle to customize screening frequency.

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An 11-year review of breast cancer diagnoses from outpatient imaging centers in western New York found that women aged 18 to 49 accounted for roughly one-fifth to one-quarter of all cases, with many tumors in those under 40 described as invasive and biologically aggressive. The findings, presented at the Radiological Society of North America meeting, underscore calls for earlier, risk-based assessment for younger women.

Researchers at Newcastle University have found that just 10 minutes of intense exercise can release molecules into the bloodstream that promote DNA repair and inhibit bowel cancer cell growth. The study, involving 30 older adults, showed significant genetic changes in cancer cells exposed to post-exercise blood. These findings suggest exercise could inspire new cancer therapies.

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Stanford Medicine researchers and collaborators report that an artificial intelligence model called SleepFM can analyze a single overnight polysomnography study and estimate a person’s future risk for more than 100 medical conditions, including dementia, heart disease and some cancers. The team says the system learns patterns across multiple physiological signals recorded during sleep and could reveal early warning signs years before clinical diagnosis.

Researchers at McMaster University and the Population Health Research Institute report that simple retinal scans, combined with genetic and blood data, may offer a non-invasive window into cardiovascular health and biological aging. An analysis of more than 74,000 people linked simpler eye-vessel patterns to higher heart-disease risk and faster aging. The study, published October 24, 2025, in Science Advances, points to potential early-detection tools that remain under investigation.

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Researchers at the Icahn School of Medicine at Mount Sinai have developed an artificial intelligence system called V2P that not only assesses whether genetic mutations are likely to be harmful but also predicts the broad categories of disease they may cause. The approach, described in a paper in Nature Communications, is intended to accelerate genetic diagnosis and support more personalized treatment, particularly for rare and complex conditions.

 

 

 

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