Martin Morgenstern: genetic editing is the future of medicine

Health economics specialist Martin Morgenstern stated in an interview that genetic editing will transform medical treatments in the coming decades. According to him, technologies like CRISPR will allow altering specific genes to combat conditions like high cholesterol. This approach promises to be more precise than traditional medications, though it carries inherent risks.

In an interview with Canal E, Martin Morgenstern, an expert in health economics, highlighted the revolutionary potential of genetic editing in medicine. He explained that this technology, particularly CRISPR, will open new pathways for managing chronic conditions by modifying specific genes and altering biological processes previously considered inevitable.

A recent example comes from the Cleveland Cardiovascular Institute, where scientists found that the natural inactivation of the ANGPTL3 gene prevents the development of high cholesterol and triglyceride levels throughout life. By reproducing this mutation through genetic editing, researchers achieved an immediate 50% reduction in cholesterol levels. Morgenstern noted that, unlike current treatments such as statins, which cause adverse effects and require chronic use, genetic editing provides more precise interventions with less reliance on ongoing drugs.

"The future of medicine is genetic editing; magic pills cease to be the destiny," emphasized the specialist. He also mentioned successful cases of terminal cancer patients who completely eliminated the disease through experimental genetic editing therapies. However, he warned of the risks of unforeseen effects if not performed with precision.

Morgenstern addressed tensions between public research and the pharmaceutical industry, which prioritizes patentable compounds over personalized genetic innovations. He highlighted ethical dilemmas in patenting biological elements, such as human genes, and urged countries to invest in academic science to distinguish real advances from marketing.

Makala yanayohusiana

Illustration of CRISPR epigenome editing tool removing red methyl tags from a holographic DNA model to activate fetal globin genes, with sickle cell blood cells normalizing, in a modern research lab.
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CRISPR-based epigenome editing switches genes on by removing methyl tags, without cutting DNA

Imeripotiwa na AI Picha iliyoundwa na AI Imethibitishwa ukweli

Researchers at UNSW Sydney and St. Jude Children’s Research Hospital report a CRISPR-derived “epigenome editing” approach that turns genes on by removing DNA methylation marks rather than cutting DNA. In cell-based experiments, they show that promoter methylation can directly—and reversibly—silence fetal globin genes, a finding they say helps settle a long-running debate about whether methylation is causal or merely correlated with gene shutdown. The work points to a potential path toward safer therapies for sickle cell disease by reactivating fetal hemoglobin without creating DNA breaks.

Researchers have developed a genomic mapping technique that reveals how thousands of genes work together to influence disease risk, helping to bridge gaps left by traditional genetic studies. The approach, described in a Nature paper led by Gladstone Institutes and Stanford University scientists, combines large-scale cell experiments with population genetics data to highlight promising targets for future therapies and deepen understanding of conditions such as blood disorders and immune-mediated diseases.

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Chinese scientist He Jiankui, who served time in prison for creating the world’s first gene-edited babies, now intends to pursue similar work to combat Alzheimer’s disease. He has criticized Silicon Valley’s efforts in the field as a “Nazi eugenic experiment.” This development revives ethical debates in biotechnology.

Researchers at Northwestern Medicine created an integrated genomic risk score that aims to predict dangerous heart rhythms early by combining rare‑variant, polygenic and whole‑genome data. The peer‑reviewed study in Cell Reports Medicine analyzed 1,119 people.

Imeripotiwa na AI Imethibitishwa ukweli

A large-scale genetic analysis of about 1.09 million people suggests that lifelong, genetically lower cholesterol—specifically non‑HDL cholesterol—is associated with substantially reduced dementia risk. Using Mendelian randomization to emulate the effects of cholesterol‑lowering drug targets such as those for statins (HMGCR) and ezetimibe (NPC1L1), the study found up to an approximately 80% lower risk per 1 mmol/L reduction for some targets. ([research-information.bris.ac.uk](https://research-information.bris.ac.uk/en/publications/cholesterollowering-drug-targets-reduce-risk-of-dementia-mendelia?utm_source=openai))

Researchers at the Icahn School of Medicine at Mount Sinai have developed an artificial intelligence system called V2P that not only assesses whether genetic mutations are likely to be harmful but also predicts the broad categories of disease they may cause. The approach, described in a paper in Nature Communications, is intended to accelerate genetic diagnosis and support more personalized treatment, particularly for rare and complex conditions.

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Researchers have produced the most detailed maps yet of how human DNA folds and reorganizes in three dimensions and over time. This work, led by scientists at Northwestern University as part of the 4D Nucleome Project, highlights how genome architecture influences gene activity and disease risk. The findings, published in Nature, could accelerate the discovery of genetic mutations linked to illnesses like cancer.

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