Hearing Loss
CPD gene mutations tied to congenital hearing loss; lab tests point to arginine and sildenafil as potential interventions
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An international team reports that rare mutations in CPD (carboxypeptidase D) cause a congenital, sensorineural form of hearing loss by disrupting arginine–nitric oxide signaling in inner‑ear hair cells. In models, arginine supplementation or sildenafil partially reversed disease‑related defects, highlighting a pathway for future therapies.
A large-scale study using UK Biobank data has found that adults with hearing loss who regularly use hearing aids face a significantly reduced risk of developing dementia. The research, published in The Lancet Healthy Longevity, highlights hearing loss treatment as a potential modifiable factor in dementia prevention. This comes amid growing evidence linking untreated hearing impairment to cognitive decline.