Study links vitamin B12 and folate to fatigue

May 29, 2026

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A new Japanese study has connected deficiencies in vitamin B12 and folate to increased fatigue and lower motivation in otherwise healthy adults. The research examined blood markers and self-reported symptoms in around 600 participants.

Researchers led by Professor Hiroaki Kanouchi at Osaka Metropolitan University analyzed blood levels of homocysteine, folate, and vitamin B12. They also assessed fatigue using the Chalder Fatigue Scale and a Visual Analog Scale while controlling for age, sleep, workload, and diet.

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Realistic illustration of a fatigued young adult overlaid with brain MRI and blood cell visuals highlighting altered ATP energy patterns linked to depression.

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Researchers studying young adults with major depressive disorder have reported an unusual energy “signature” in both the brain and immune blood cells: higher ATP-related measures at rest, paired with a reduced ability to increase energy production when demand rises. The findings, published in Translational Psychiatry, may help explain common symptoms such as fatigue and low motivation, though the work is early and based on a small sample.

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May 27, 2026 በAI የተዘገበ

Scientists are raising new questions about the relationship between vitamin B12 and cancer risk. While deficiency has long been known to increase dangers, recent studies suggest very high levels may also play a role.

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Researchers at the University of California, San Francisco report that higher levels of the iron-associated protein FTL1 in the hippocampus of older mice are tied to weaker neural connections and worse performance on cognitive tests. In the experiments, reducing FTL1 in older mice was associated with increased neuronal connectivity and improved memory performance, findings published in Nature Aging.

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March 09, 2026 በAI የተዘገበ እውነት ተፈትሸ

Teenagers and young adults who reported using pre-workout dietary supplements were more than twice as likely as non-users to say they slept five hours or less per night, according to an analysis of Canadian survey data published in the journal Sleep Epidemiology.

May 20, 2026 20:53

Study links vitamin B12 and folate to fatigue

ተያያዥ ጽሁፎች

Study links major depression in young adults to altered cellular energy patterns in brain and blood

Study finds lower normal B12 levels tied to brain changes

Researchers question vitamin B12 levels and cancer links

Doctors warn biotin supplements can interfere with some cancer-related blood tests

Japanese scientists develop enhanced vitamin K for neuron regeneration

Brain protein decline linked to aging in mice study

Study links daily mental sharpness to productivity gains

UCSF study links iron-associated protein FTL1 to age-related memory decline in mice

Large VIVID trial finds high-dose vitamin D3 did not lessen acute COVID-19 severity, but adherence analysis suggests possible long COVID signal

Study links pre-workout supplement use to very short sleep among teens and young adults

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