Study links vitamin B12 and folate to fatigue

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A new Japanese study has connected deficiencies in vitamin B12 and folate to increased fatigue and lower motivation in otherwise healthy adults. The research examined blood markers and self-reported symptoms in around 600 participants.

Researchers led by Professor Hiroaki Kanouchi at Osaka Metropolitan University analyzed blood levels of homocysteine, folate, and vitamin B12. They also assessed fatigue using the Chalder Fatigue Scale and a Visual Analog Scale while controlling for age, sleep, workload, and diet.

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Illustration of a woman with depression symptoms overlaid with microscopic view of aging monocytes in blood, linking to study on women with and without HIV.
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Study links monocyte “biological aging” in blood to emotional depression symptoms in women with and without HIV

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A study of 440 participants from the Women’s Interagency HIV Study found that accelerated epigenetic aging in monocytes—an immune cell type—tracked more closely with emotional and cognitive depression symptoms such as hopelessness and loss of pleasure than with physical symptoms like fatigue. The work, published in The Journals of Gerontology: Series A, adds evidence that cell-type-specific aging measures could contribute to future biological tools to complement symptom-based depression screening, though researchers say more validation is needed before clinical use.

Study finds lower normal B12 levels tied to brain changes

A University of California San Francisco study has linked lower but still normal levels of active vitamin B12 to slower thinking and white matter damage in healthy older adults. The research, published in Annals of Neurology in 2025, suggests current guidelines may miss early neurological risks. Researchers examined 231 participants with an average age of 71.

Researchers question vitamin B12 levels and cancer links

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Scientists are raising new questions about the relationship between vitamin B12 and cancer risk. While deficiency has long been known to increase dangers, recent studies suggest very high levels may also play a role.

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Doctors warn biotin supplements can interfere with some cancer-related blood tests

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Japanese scientists develop enhanced vitamin K for neuron regeneration

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Brain protein decline linked to aging in mice study

Review urges a shift from minimum to “optimal” protein and exercise guidance, author says

A new perspective article in Frontiers in Nutrition argues that public health advice on protein intake and physical activity is largely designed to prevent deficiency, and that many people may benefit from aiming above today’s minimum recommendations to support strength, independence and cognitive function as they age.

Low vitamin D linked to higher pain after breast cancer surgery

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Women with vitamin D deficiency face significantly more pain and greater opioid use following breast cancer surgery, according to new research. The study found deficient patients were three times more likely to experience moderate to severe discomfort in the first day after mastectomy.

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Creatine shows mixed results as potential depression treatment

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Study finds vitamin D deficiency persists year-round among older and minoritized ethnic adults in northern Britain

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Review finds calcium and vitamin D supplements offer little benefit

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UK Biobank study links higher blood tyrosine to slightly shorter lifespan in men

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