Studi kaitkan vitamin B12 dan folat dengan kelelahan

Sebuah studi baru asal Jepang telah menghubungkan kekurangan vitamin B12 dan folat dengan peningkatan rasa lelah dan penurunan motivasi pada orang dewasa yang sehat. Penelitian ini memeriksa penanda darah dan gejala yang dilaporkan sendiri oleh sekitar 600 peserta.

Para peneliti yang dipimpin oleh Profesor Hiroaki Kanouchi di Osaka Metropolitan University menganalisis kadar homosistein, folat, dan vitamin B12 dalam darah. Mereka juga menilai kelelahan menggunakan Chalder Fatigue Scale dan Visual Analog Scale dengan mengontrol faktor usia, tidur, beban kerja, dan pola makan.

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Illustration of a woman with depression symptoms overlaid with microscopic view of aging monocytes in blood, linking to study on women with and without HIV.
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Study links monocyte “biological aging” in blood to emotional depression symptoms in women with and without HIV

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A study of 440 participants from the Women’s Interagency HIV Study found that accelerated epigenetic aging in monocytes—an immune cell type—tracked more closely with emotional and cognitive depression symptoms such as hopelessness and loss of pleasure than with physical symptoms like fatigue. The work, published in The Journals of Gerontology: Series A, adds evidence that cell-type-specific aging measures could contribute to future biological tools to complement symptom-based depression screening, though researchers say more validation is needed before clinical use.

A University of California San Francisco study has linked lower but still normal levels of active vitamin B12 to slower thinking and white matter damage in healthy older adults. The research, published in Annals of Neurology in 2025, suggests current guidelines may miss early neurological risks. Researchers examined 231 participants with an average age of 71.

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Scientists are raising new questions about the relationship between vitamin B12 and cancer risk. While deficiency has long been known to increase dangers, recent studies suggest very high levels may also play a role.

A new perspective article in Frontiers in Nutrition argues that public health advice on protein intake and physical activity is largely designed to prevent deficiency, and that many people may benefit from aiming above today’s minimum recommendations to support strength, independence and cognitive function as they age.

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Women with vitamin D deficiency face significantly more pain and greater opioid use following breast cancer surgery, according to new research. The study found deficient patients were three times more likely to experience moderate to severe discomfort in the first day after mastectomy.

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