日本で行われた新たな研究により、健康な成人においてビタミンB12と葉酸の不足が疲労感の増大や意欲低下につながることが明らかになりました。この研究では、約600人の参加者を対象に血液検査と自己申告による症状調査が行われました。
大阪公立大学の叶内宏明教授らの研究チームは、血中のホモシステイン、葉酸、ビタミンB12の濃度を分析しました。また、年齢、睡眠、労働負荷、食生活を調整した上で、チャルダー疲労尺度および視覚的アナログ尺度を用いて疲労度を評価しました。
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A study of 440 participants from the Women’s Interagency HIV Study found that accelerated epigenetic aging in monocytes—an immune cell type—tracked more closely with emotional and cognitive depression symptoms such as hopelessness and loss of pleasure than with physical symptoms like fatigue. The work, published in The Journals of Gerontology: Series A, adds evidence that cell-type-specific aging measures could contribute to future biological tools to complement symptom-based depression screening, though researchers say more validation is needed before clinical use.
A University of California San Francisco study has linked lower but still normal levels of active vitamin B12 to slower thinking and white matter damage in healthy older adults. The research, published in Annals of Neurology in 2025, suggests current guidelines may miss early neurological risks. Researchers examined 231 participants with an average age of 71.
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Scientists are raising new questions about the relationship between vitamin B12 and cancer risk. While deficiency has long been known to increase dangers, recent studies suggest very high levels may also play a role.
A new perspective article in Frontiers in Nutrition argues that public health advice on protein intake and physical activity is largely designed to prevent deficiency, and that many people may benefit from aiming above today’s minimum recommendations to support strength, independence and cognitive function as they age.
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Women with vitamin D deficiency face significantly more pain and greater opioid use following breast cancer surgery, according to new research. The study found deficient patients were three times more likely to experience moderate to severe discomfort in the first day after mastectomy.