カリフォルニア大学サンフランシスコ校の研究チームは、健康な高齢者において、正常範囲内であっても活性ビタミンB12の濃度が低いことが、思考力の低下や白質損傷と関連していることを明らかにしました。2025年に「Annals of Neurology」誌で発表されたこの研究は、現在のガイドラインでは神経学的なリスクの早期発見を見逃している可能性があることを示唆しています。研究対象は平均年齢71歳の231人です。
この研究は、認知症や軽度認知障害のない高齢者に焦点を当てました。参加者の血中ビタミンB12濃度の平均は414.8 pmol/Lで、米国の最低基準である148 pmol/Lを大きく上回っていました。年齢、性別、教育歴、心血管疾患のリスクを調整した結果、活性ビタミンB12の濃度が低い層では、処理速度の低下や視覚的反応の遅延が見られました。
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Researchers studying young adults with major depressive disorder have reported an unusual energy “signature” in both the brain and immune blood cells: higher ATP-related measures at rest, paired with a reduced ability to increase energy production when demand rises. The findings, published in Translational Psychiatry, may help explain common symptoms such as fatigue and low motivation, though the work is early and based on a small sample.
A new study has found that adults with higher vitamin D levels in their 30s and 40s tend to have lower levels of tau protein in their brains about 16 years later. Tau is a key biomarker associated with dementia. The research, published this week, highlights a potential modifiable risk factor for brain health.
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New research from the University of Southern California suggests that subtle declines in brain blood flow and oxygen delivery may be early indicators of Alzheimer's disease. The study, published in Alzheimer's and Dementia, used noninvasive scans to connect vascular health with amyloid plaques and hippocampal shrinkage. These findings highlight the role of brain circulation in the disease process beyond traditional markers like amyloid and tau.
Scientists at Washington University School of Medicine in St. Louis have developed a blood test that estimates when Alzheimer's symptoms may begin, using levels of the protein p-tau217. The model predicts onset within about three to four years, potentially aiding clinical trials and early interventions. This advance relies on data from 603 older adults in ongoing studies.
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Researchers at the University of California, San Francisco report that higher levels of the iron-associated protein FTL1 in the hippocampus of older mice are tied to weaker neural connections and worse performance on cognitive tests. In the experiments, reducing FTL1 in older mice was associated with increased neuronal connectivity and improved memory performance, findings published in Nature Aging.