Une étude lie des niveaux normaux bas de vitamine B12 à des changements cérébraux

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Une étude de l'Université de Californie à San Francisco a établi un lien entre des niveaux d'active vitamine B12 plus bas, bien que restant dans la normale, et un ralentissement de la pensée ainsi que des lésions de la substance blanche chez des personnes âgées en bonne santé. Les travaux, publiés dans les Annals of Neurology en 2025, suggèrent que les recommandations actuelles pourraient occulter des risques neurologiques précoces. Les chercheurs ont examiné 231 participants âgés en moyenne de 71 ans.

L'étude s'est concentrée sur des personnes âgées ne présentant ni démence ni troubles cognitifs légers. Les participants avaient un taux sanguin moyen de B12 de 414,8 pmol/L, bien au-dessus du minimum américain de 148 pmol/L. Ceux ayant un taux de B12 active plus faible ont montré une vitesse de traitement ralentie et des réponses visuelles retardées après ajustement en fonction de l'âge, du sexe, du niveau d'éducation et des risques cardiovasculaires.

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