Un estudio relaciona niveles normales bajos de vitamina B12 con cambios cerebrales

Un estudio de la Universidad de California en San Francisco ha relacionado niveles bajos, pero aún normales, de vitamina B12 activa con un pensamiento más lento y daños en la materia blanca en adultos mayores sanos. La investigación, publicada en Annals of Neurology en 2025, sugiere que las directrices actuales podrían pasar por alto riesgos neurológicos tempranos. Los investigadores examinaron a 231 participantes con una edad promedio de 71 años.

El estudio se centró en adultos mayores sin demencia ni deterioro cognitivo leve. Los participantes tenían un nivel sanguíneo promedio de B12 de 414.8 pmol/L, muy por encima del mínimo estadounidense de 148 pmol/L. Aquellos con niveles más bajos de B12 activa mostraron una velocidad de procesamiento más lenta y respuestas visuales retrasadas tras realizar ajustes por edad, sexo, educación y riesgos cardiovasculares.

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