Study links vitamin B12 and folate to fatigue

May 29, 2026

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A new Japanese study has connected deficiencies in vitamin B12 and folate to increased fatigue and lower motivation in otherwise healthy adults. The research examined blood markers and self-reported symptoms in around 600 participants.

Researchers led by Professor Hiroaki Kanouchi at Osaka Metropolitan University analyzed blood levels of homocysteine, folate, and vitamin B12. They also assessed fatigue using the Chalder Fatigue Scale and a Visual Analog Scale while controlling for age, sleep, workload, and diet.

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Realistic illustration of a fatigued young adult overlaid with brain MRI and blood cell visuals highlighting altered ATP energy patterns linked to depression.

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May 20, 2026 20:53

Study links vitamin B12 and folate to fatigue

Awọn iroyin ti o ni ibatan

Study links major depression in young adults to altered cellular energy patterns in brain and blood

Study finds lower normal B12 levels tied to brain changes

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