Pharmacology
Stevia compound enhances minoxidil for treating hair loss
11. oktober 2025 Rapporteret af AI
Researchers have found that stevioside, a natural sweetener from the Stevia plant, improves the skin absorption of minoxidil, a common treatment for pattern baldness. In mouse tests, a patch combining the two stimulated hair growth by reactivating follicles. This approach could lead to more effective natural therapies for millions affected by androgenetic alopecia.
Scientists discover protein that switches off hunger
5. oktober 2025 Rapporteret af AI
Researchers have identified how a protein called MRAP2 regulates hunger by transporting the brain receptor MC4R to the cell surface, enhancing appetite-suppressing signals. This finding, from a study involving institutions in Germany, Canada, and the UK, could lead to new obesity treatments. The work was published in Nature Communications.
Higher semaglutide dose boosts weight loss in obesity trials
Two phase 3 clinical trials show that a 7.2 mg weekly dose of semaglutide leads to greater weight loss than the approved 2.4 mg dose in adults with obesity, including those with type 2 diabetes. Nearly half of participants on the higher dose lost 20% or more of their body weight over 72 weeks. The results, published in The Lancet Diabetes & Endocrinology, suggest improved metabolic health with a favorable safety profile.
Cellular switch discovery offers hope for Parkinson's treatment
Scientists have identified a key cellular regulator called PP2A-B55alpha that balances mitochondrial health, potentially leading to new therapies for Parkinson's disease. In preclinical models, reducing its activity improved motor symptoms and mitochondrial function. The findings, published in Science Advances, could extend to other mitochondrial disorders and cancer.