Scientists uncover brain circuit that overrides chronic pain

October 11, 2025 Ti AI ṣe iroyin

Researchers at the University of Pennsylvania have identified a group of brainstem neurons that can suppress chronic pain signals when survival needs like hunger or fear arise. These Y1 receptor neurons in the lateral parabrachial nucleus act as a neural switchboard, prioritizing urgent biological demands over persistent discomfort. The discovery, published in Nature, offers potential new avenues for pain treatments.

Higher semaglutide dose boosts weight loss in obesity trials

October 05, 2025 Ti AI ṣe iroyin

Two phase 3 clinical trials show that a 7.2 mg weekly dose of semaglutide leads to greater weight loss than the approved 2.4 mg dose in adults with obesity, including those with type 2 diabetes. Nearly half of participants on the higher dose lost 20% or more of their body weight over 72 weeks. The results, published in The Lancet Diabetes & Endocrinology, suggest improved metabolic health with a favorable safety profile.

Stevia compound enhances minoxidil for treating hair loss

Researchers have found that stevioside, a natural sweetener from the Stevia plant, improves the skin absorption of minoxidil, a common treatment for pattern baldness. In mouse tests, a patch combining the two stimulated hair growth by reactivating follicles. This approach could lead to more effective natural therapies for millions affected by androgenetic alopecia.

Scientists discover protein that switches off hunger

Researchers have identified how a protein called MRAP2 regulates hunger by transporting the brain receptor MC4R to the cell surface, enhancing appetite-suppressing signals. This finding, from a study involving institutions in Germany, Canada, and the UK, could lead to new obesity treatments. The work was published in Nature Communications.