Pharmacology

Researchers report designing and testing five fluorinated, reversible carbamate derivatives of psilocin—psilocybin’s active metabolite—aimed at reducing acute psychedelic-like effects while preserving key serotonin-receptor activity. In experiments in mice, a lead compound labeled 4e produced lower but longer-lasting brain exposure to psilocin-related activity and triggered fewer head-twitch responses than pharmaceutical-grade psilocybin, according to a study in the Journal of Medicinal Chemistry.

2 марта 2026 Сообщено ИИ

Researchers have discovered why polyamines, compounds promoted for anti-aging benefits, may also promote cancer growth. The study shows that these molecules activate different proteins in healthy versus cancerous cells, leading to contrasting effects. Led by experts at Tokyo University of Science, the findings were published in the Journal of Biological Chemistry.

Researchers have discovered that a byproduct of vitamin A, all-trans retinoic acid, weakens the immune system's fight against cancer and reduces the effectiveness of certain vaccines. In preclinical studies, a new drug called KyA33 blocks this pathway, enhancing immune responses and slowing tumor growth. The findings, from two studies, explain a long-standing paradox about vitamin A's role in cancer.

16 января 2026 Сообщено ИИ

Researchers at Ben-Gurion University have identified the protein SIRT6 as a key regulator of tryptophan metabolism in the brain, explaining how its loss leads to toxic byproducts in aging and diseased brains. The study reveals that declining SIRT6 shifts tryptophan toward harmful pathways, reducing protective neurotransmitters like serotonin and melatonin. Blocking a related enzyme showed potential for reversing brain damage in models.

Researchers have discovered that combining silybin and carvedilol is more effective against liver fibrosis than either drug alone. The pair targets key drivers of liver scarring, reducing collagen buildup in experimental models. Both drugs are already approved for other uses, paving the way for quick clinical testing.

27 декабря 2025 Сообщено ИИ

Scientists at UBC Okanagan have identified the enzymes plants use to produce mitraphylline, a rare compound with potential anti-cancer properties. This breakthrough solves a long-standing mystery and paves the way for sustainable production of such molecules. The discovery highlights plants' untapped potential in medicine.