Pharmacology

USF Health scientists in a lab studying reversed mu opioid receptor signaling for safer painkillers, with molecular models, graphs, and journal references.

USF Health studies suggest new opioid-receptor signaling step could guide development of safer painkillers

7 Mwezi wa kwanza, 2026 Imeripotiwa na AI Picha iliyoundwa na AI Imethibitishwa ukweli

Researchers at USF Health report evidence that an early step in mu opioid receptor signaling can run in reverse, and that certain experimental compounds can enhance morphine- and fentanyl-driven pain relief in lab tests without increasing respiratory suppression at very low doses. The findings, published Dec. 17 in Nature and Nature Communications, are framed as a blueprint for designing longer-lasting opioids with fewer risks, though the newly tested molecules are not considered clinical drug candidates.

Statins block cancer's PD-L1 evasion in immunotherapy

Researchers in Japan have uncovered how cancer cells use tiny vesicles to spread the immune-suppressing protein PD-L1, explaining why immunotherapy often fails. A protein called UBL3 directs this process, but common statins can disrupt it, potentially boosting treatment effectiveness. The findings, from patient samples and lab tests, suggest a simple way to improve outcomes for lung cancer patients.

Scientists uncover molecule to combat drug-resistant fungi

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After 11 years of research, scientists at McMaster University have identified a molecule called butyrolactol A that weakens deadly fungi, making them vulnerable to existing treatments. This discovery targets pathogens like Cryptococcus neoformans, which pose severe risks to immunocompromised individuals. The finding could revive outdated antifungal drugs amid rising resistance.

Teknolojia

MIT engineers create smart pill to track medication adherence

Afya

Study finds Tamiflu reduces neuropsychiatric risks in children with flu

Afya

Drug pair shows promise for treating liver fibrosis

Researchers decode rare cancer-fighting plant compound

Scientists at UBC Okanagan have identified the enzymes plants use to produce mitraphylline, a rare compound with potential anti-cancer properties. This breakthrough solves a long-standing mystery and paves the way for sustainable production of such molecules. The discovery highlights plants' untapped potential in medicine.

Study finds tramadol's pain relief modest but risks elevated

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A comprehensive review of clinical trials indicates that tramadol, a widely prescribed opioid for chronic pain, offers only slight relief that may not be noticeable to many patients. However, it significantly increases the risk of serious side effects, particularly heart-related issues. Researchers recommend minimizing its use due to these concerns.

Review uncovers limited benefits of medical cannabis

A comprehensive analysis of over 2,500 studies shows that medical cannabis has strong evidence for only a few specific uses, despite widespread public belief in its broader effectiveness. Led by UCLA Health researchers, the review highlights gaps between perceptions and scientific proof for conditions like chronic pain and anxiety. It also identifies potential risks, particularly for adolescents and daily users.

Scientists identify cell-death enzyme that helps cancer cells survive treatment

11 Mwezi wa kumi na mbili, 2025 Imeripotiwa na AI Imethibitishwa ukweli

Researchers at the University of California San Diego report that certain cancer cells survive targeted therapies by using low-level activation of a cell-death–linked enzyme, enabling them to endure treatment and later regrow tumors. Because this resistance mechanism does not depend on new genetic mutations, it appears early in treatment and may offer a new target to help prevent tumor relapse.

Jumanne, 20. Mwezi wa kwanza 2026, 23:46:13