Healthy Aging
Blood protein CtBP2 tied to metabolism and markers of healthy aging
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University of Tsukuba researchers report that CtBP2, a metabolic sensor protein detected in the bloodstream, tracks with age and health status in people—declining with age, remaining higher in members of long‑lived families, and falling in those with advanced diabetic complications.
Naked mole-rats' cGAS mutations enhance DNA repair and longevity
Scientists have uncovered how naked mole-rats achieve exceptional longevity through subtle changes in a key immune protein. These mutations in the enzyme cGAS improve DNA repair, potentially explaining why the rodents live up to 40 years. The findings, tested in fruit flies, suggest broader implications for understanding aging.
Mild dietary stress promotes healthier aging in worms
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Researchers at the University of Basel have discovered that specific RNA molecules in nematodes' diets trigger a mild stress response that enhances cellular health and extends healthspan. This process prevents toxic protein buildup associated with aging and diseases like Alzheimer's and Parkinson's. The findings, published in Nature Communications, suggest diet influences how well organisms age.