Struktur cetak 3D dapat mempercepat terapi sel T CAR

Para peneliti telah mengembangkan gel cetak 3D yang meniru kelenjar getah bening untuk meningkatkan produksi sel T CAR bagi pengobatan kanker. Pendekatan ini meningkatkan tingkat keberhasilan dan mempercepat pertumbuhan sel dibandingkan dengan metode standar. Hal ini dapat membantu menekan biaya dan memperluas akses terhadap terapi tersebut di seluruh dunia.

Proses standar pembuatan sel T CAR melibatkan pengambilan sel T dari pasien, merekayasa genetika sel tersebut dengan virus untuk menargetkan kanker, dan memperbanyaknya selama beberapa minggu. Proses ini bisa memakan biaya lebih dari £280.000 per putaran dan sering kali memakan waktu hingga satu bulan, sehingga membatasi ketersediaannya, terutama di negara-negara berpenghasilan rendah.

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Illustration of a German woman achieving complete remission from three autoimmune diseases via groundbreaking CAR-T therapy, symbolizing hope and medical triumph.
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CAR-T therapy achieves complete remission of three autoimmune diseases in German woman

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A 47-year-old woman bedridden with autoimmune hemolytic anemia, immune thrombocytopenia, and antiphospholipid syndrome has achieved complete remission after CAR-T cell therapy at University Hospital Erlangen in Germany. Treated by Fabian Müller after nine failed therapies, she recovered rapidly and remains healthy over a year later without medication—the first simultaneous treatment of multiple autoimmune diseases with this method.

Researchers have found that making cancer cells stiffer can enhance the effectiveness of car t-cell therapy against aggressive tumors. In experiments with mice, the approach led to complete tumor disappearance in some cases. The findings were presented recently at a conference in London.

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A small study has found that CAR-T cell therapy may offer a new way to manage HIV over the long term. The approach, already used to treat certain cancers, involves engineering a patient’s own immune cells.

Caribou Biosciences discussed progress on its off-the-shelf CAR-T therapies during a presentation at the Bank of America Global Healthcare Conference on May 13. Chief executive Rachel Haurwitz highlighted Phase I data for two programs that target lymphoma and multiple myeloma.

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Scientists at McMaster University and the Hospital for Sick Children in Canada have discovered that oligodendrocytes, cells typically supporting nerve function, aid the growth of glioblastoma by sending signals to tumor cells. Blocking this communication slowed tumor progression in lab models. The findings suggest an existing HIV drug, Maraviroc, could be repurposed for treatment.

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