Tes ApoB lebih efektif daripada LDL untuk panduan perawatan kolesterol

Sebuah studi baru menunjukkan bahwa pengukuran apolipoprotein B dapat membantu mencegah serangan jantung dan stroke lebih banyak dibandingkan tes kolesterol LDL standar yang digunakan oleh jutaan orang Amerika.

Para peneliti di Northwestern University memodelkan hasil bagi 250.000 orang dewasa yang memenuhi syarat untuk terapi statin. Mereka membandingkan tiga strategi untuk mengintensifkan pengobatan ketika target tidak tercapai: LDL di bawah 100 mg/dL, non-HDL di bawah 118 mg/dL, dan ApoB di bawah 78,7 mg/dL. Pendekatan ApoB mencegah lebih banyak kejadian kardiovaskular dan terbukti hemat biaya bagi pembayar layanan kesehatan di AS, menurut analisis yang diterbitkan dalam JAMA. Penulis utama Ciaran Kohli-Lynch mencatat bahwa tes tersebut menghitung partikel berbahaya secara lebih langsung daripada pengukuran konvensional. Temuan ini muncul seiring dengan pedoman terbaru yang mendorong terapi penurun kolesterol lebih dini. Rekan penulis termasuk John Wilkins dan Samuel Luebbe. Studi ini menerima dukungan dari American Heart Association.

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Scientific illustration of HELZ2 protein in the liver regulating cholesterol release.
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UT Southwestern researchers identify HELZ2 protein that controls the liver’s release of cholesterol-carrying particles

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Scientists at UT Southwestern Medical Center report they have identified a protein, HELZ2, that acts as a key regulator of how many cholesterol-carrying particles the liver releases into the bloodstream by affecting the gene APOB. The study was published in the American Heart Association journal Circulation and could inform future research into heart disease and fatty liver disease.

An experimental therapy called VERVE-102 lowered LDL cholesterol by up to 62 percent after a single dose in an early safety study. The results come from a Phase I trial involving 35 patients with high cholesterol or early cardiovascular disease. Data were published this week in the New England Journal of Medicine.

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Researchers from the University of Barcelona and the University of Oregon report that short DNA molecules known as polypurine reverse Hoogsteen hairpins (PPRHs) suppressed the PCSK9 gene and reduced blood cholesterol in a mouse model. In transgenic mice carrying the human PCSK9 gene, a single injection of one candidate (HpE12) cut plasma PCSK9 by 50% and total cholesterol by 47% three days later, according to findings published in Biochemical Pharmacology.

Research presented at ASM Microbe 2026 reported that removing a bile acid receptor called FXR reduced artery plaque in mice exposed to sleep apnea-like conditions, pointing to a potential gut-driven pathway behind cardiovascular risk.

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A major Cochrane review of 17 clinical trials involving over 20,000 participants has concluded that drugs targeting amyloid beta in the brain provide no meaningful benefits for patients with mild cognitive impairment or early Alzheimer’s. These treatments also raise the risk of brain swelling and bleeding. Researchers urge a shift to alternative pathways for future treatments.

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