Peneliti USC identifikasi senyawa yang menargetkan peradangan otak pada penyakit Alzheimer

Selasa, 26 Mei 2026

Dilaporkan oleh AI

Para ilmuwan di University of Southern California telah menemukan senyawa eksperimental yang dapat mengurangi peradangan otak berbahaya yang terkait dengan penyakit Alzheimer. Penelitian ini berfokus pada enzim cPLA2 dan orang-orang yang membawa gen APOE4 berisiko tinggi.

Para peneliti di University of Southern California mengidentifikasi senyawa yang secara selektif menghambat cPLA2, sebuah enzim yang dikaitkan dengan peradangan di otak. Temuan ini diterbitkan dalam jurnal npj Drug Discovery pada tahun 2026. Tim tersebut menghubungkan aktivitas cPLA2 yang lebih tinggi dengan risiko Alzheimer yang lebih besar di antara para pembawa gen APOE4, meskipun enzim tersebut juga mendukung fungsi otak yang normal.

Oregon State researchers track copper-driven amyloid clumping in real time, testing a copper-selective chelator

Selasa, 07 April 2026 Dilaporkan oleh AI Gambar dihasilkan oleh AI Fakta terverifikasi

Oregon State University scientists report they have monitored, second by second, how copper ions promote aggregation of amyloid-beta—an Alzheimer’s-associated protein—and how different metal-binding molecules can disrupt or reverse that clumping, using a fluorescence anisotropy approach described in a study published in ACS Omega.

Scientists call for multi-pronged strategies against Alzheimer's

A team of researchers led by Professor Yan-Jiang Wang has published a review arguing that Alzheimer's disease requires integrated treatments targeting multiple factors, not single causes. New drugs like lecanemab and donanemab offer modest benefits by slowing decline, but fall short of reversal. The paper, in Science China Life Sciences, emphasizes genetics, aging, and systemic health alongside amyloid-beta and tau proteins.

Study links Alzheimer's origins to peripheral inflammation

Kamis, 05 Maret 2026 Dilaporkan oleh AI

A new genomic analysis suggests that Alzheimer's disease may begin with inflammation in organs like the skin, lungs, or gut, potentially decades before brain symptoms appear. Researchers analyzed genetic data from hundreds of thousands of people and found risk genes more active outside the brain. This perspective could reshape prevention and treatment strategies.

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Researchers at Case Western Reserve University report that some gut bacteria can make unusually inflammatory forms of glycogen and that this microbial glycogen can trigger immune activity linked to brain inflammation in models of disease tied to the C9orf72 mutation. In patient stool samples, the team found these glycogen forms more often in ALS and C9orf72-related frontotemporal dementia than in healthy controls, and enzymatically breaking down glycogen in the gut improved outcomes in mice.

Higher meat intake slows Alzheimer's decline for APOE4 carriers, Karolinska study shows

Kamis, 19 Maret 2026 Dilaporkan oleh AI

Older adults carrying high-risk APOE4 gene variants experienced slower cognitive decline and lower dementia risk with higher meat consumption, according to a Karolinska Institutet study of over 2,100 participants tracked for up to 15 years. Findings suggest diet's effects on brain health vary by genetics, challenging one-size-fits-all advice.

20 Mei 2026 09.20

Peneliti USC identifikasi senyawa yang menargetkan peradangan otak pada penyakit Alzheimer

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