وجد علماء في جامعة جنوب كاليفورنيا مركبات تجريبية قد تقلل من التهاب الدماغ الضار المرتبط بمرض ألزهايمر. يركز العمل على إنزيم cPLA2 والأشخاص الذين يحملون جين APOE4 عالي الخطورة.
حدد باحثون في جامعة جنوب كاليفورنيا مركبات تثبط بشكل انتقائي إنزيم cPLA2، وهو إنزيم مرتبط بالالتهاب في الدماغ. نُشرت النتائج في دورية npj Drug Discovery في عام 2026. وربط الفريق بين زيادة نشاط إنزيم cPLA2 وارتفاع خطر الإصابة بمرض ألزهايمر لدى حاملي جين APOE4، على الرغم من أن هذا الإنزيم يدعم أيضاً وظائف الدماغ الطبيعية.
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Oregon State University scientists report they have monitored, second by second, how copper ions promote aggregation of amyloid-beta—an Alzheimer’s-associated protein—and how different metal-binding molecules can disrupt or reverse that clumping, using a fluorescence anisotropy approach described in a study published in ACS Omega.
A team of researchers led by Professor Yan-Jiang Wang has published a review arguing that Alzheimer's disease requires integrated treatments targeting multiple factors, not single causes. New drugs like lecanemab and donanemab offer modest benefits by slowing decline, but fall short of reversal. The paper, in Science China Life Sciences, emphasizes genetics, aging, and systemic health alongside amyloid-beta and tau proteins.
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A new genomic analysis suggests that Alzheimer's disease may begin with inflammation in organs like the skin, lungs, or gut, potentially decades before brain symptoms appear. Researchers analyzed genetic data from hundreds of thousands of people and found risk genes more active outside the brain. This perspective could reshape prevention and treatment strategies.
Researchers at Case Western Reserve University report that some gut bacteria can make unusually inflammatory forms of glycogen and that this microbial glycogen can trigger immune activity linked to brain inflammation in models of disease tied to the C9orf72 mutation. In patient stool samples, the team found these glycogen forms more often in ALS and C9orf72-related frontotemporal dementia than in healthy controls, and enzymatically breaking down glycogen in the gut improved outcomes in mice.
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Older adults carrying high-risk APOE4 gene variants experienced slower cognitive decline and lower dementia risk with higher meat consumption, according to a Karolinska Institutet study of over 2,100 participants tracked for up to 15 years. Findings suggest diet's effects on brain health vary by genetics, challenging one-size-fits-all advice.