Forskare vid USC identifierar substanser som angriper hjärninflammation vid Alzheimers sjukdom

Forskare vid University of Southern California har hittat experimentella substanser som kan reducera den skadliga hjärninflammation som förknippas med Alzheimers sjukdom. Arbetet fokuserar på enzymet cPLA2 och personer som bär på högriskgenen APOE4.

Forskare vid University of Southern California har identifierat substanser som selektivt hämmar cPLA2, ett enzym kopplat till inflammation i hjärnan. Resultaten publicerades i tidskriften npj Drug Discovery under 2026. Forskarlaget kopplade högre cPLA2-aktivitet till en ökad risk för Alzheimers hos APOE4-bärare, trots att enzymet även stödjer normal hjärnfunktion.

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