Exame de ApoB supera o LDL na orientação do tratamento do colesterol

Um novo estudo indica que medir a apolipoproteína B pode ajudar a prevenir mais ataques cardíacos e derrames do que o teste de colesterol LDL padrão usado por milhões de americanos.

Pesquisadores da Northwestern University modelaram os resultados para 250.000 adultos elegíveis para terapia com estatinas. Eles compararam três estratégias para intensificar o tratamento quando as metas não eram atingidas: LDL abaixo de 100 mg/dL, não-HDL abaixo de 118 mg/dL e ApoB abaixo de 78,7 mg/dL. O método da ApoB preveniu mais eventos cardiovasculares e provou ser rentável para os pagadores do sistema de saúde dos EUA, de acordo com a análise publicada no JAMA. O autor principal, Ciaran Kohli-Lynch, observou que o teste contabiliza as partículas nocivas de forma mais direta do que as medidas convencionais. As descobertas surgem em um momento em que as diretrizes atualizadas incentivam a terapia de redução de colesterol mais precoce. Os coautores incluem John Wilkins e Samuel Luebbe. O estudo recebeu apoio da American Heart Association.

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Scientific illustration of HELZ2 protein in the liver regulating cholesterol release.
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UT Southwestern researchers identify HELZ2 protein that controls the liver’s release of cholesterol-carrying particles

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Scientists at UT Southwestern Medical Center report they have identified a protein, HELZ2, that acts as a key regulator of how many cholesterol-carrying particles the liver releases into the bloodstream by affecting the gene APOB. The study was published in the American Heart Association journal Circulation and could inform future research into heart disease and fatty liver disease.

An experimental therapy called VERVE-102 lowered LDL cholesterol by up to 62 percent after a single dose in an early safety study. The results come from a Phase I trial involving 35 patients with high cholesterol or early cardiovascular disease. Data were published this week in the New England Journal of Medicine.

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Researchers from the University of Barcelona and the University of Oregon report that short DNA molecules known as polypurine reverse Hoogsteen hairpins (PPRHs) suppressed the PCSK9 gene and reduced blood cholesterol in a mouse model. In transgenic mice carrying the human PCSK9 gene, a single injection of one candidate (HpE12) cut plasma PCSK9 by 50% and total cholesterol by 47% three days later, according to findings published in Biochemical Pharmacology.

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